A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis

被引：0
作者：
Sang Jun Han
Shannon M Hawkins
Khurshida Begum
Sung Yun Jung
Ertug Kovanci
Jun Qin
John P Lydon
Francesco J DeMayo
Bert W O'Malley
机构：
[1] Baylor College of Medicine,Department of Molecular and Cellular Biology
[2] Baylor College of Medicine,Department of Obstetrics
[3] Baylor College of Medicine,Department of Gynecology
[4] Center for Molecular Discovery,Department of Biochemistry and Molecular Biology
[5] Verna and Marrs McLean,undefined
[6] Baylor College of Medicine,undefined
来源：
Nature Medicine | 2012年 / 18卷
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摘要：
Endometriosis afflicts ~15% of women of reproductive age, causing pelvic pain, and is often associated with infertility. In a new study, Bert O'Malley and his colleagues now show that in response to TNF-α signaling, a unique isoform of SRC-1, an estrogen receptor coactivator, is elevated in endometriotic tissue, preventing the normal apoptosis of these cells. These results could explain the proliferation of these cells, while also further suggesting the antibody to TNF-α etanercept as a therapy for this condition.
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页码：1102 / 1111
页数：9
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共 104 条
[21]  
Tamaya T(2011)Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis Fertil. Steril. 96 113-117
[22]  
Harris HA(2001)Expression of estrogen receptor α and β in peritoneal and ovarian endometriosis Fertil. Steril. 75 1198-1205
[23]  
Bruner-Tran KL(2001)Interleukin 1β, interleukin-6, and tumor necrosis factor-α in endometriotic tissue and in endometrium Fertil. Steril. 75 489-495
[24]  
Zhang X(2002)Increased expression of cyclooxygenase-2 in local lesions of endometriosis patients Am. J. Reprod. Immunol. 48 50-56
[25]  
Osteen KG(2005)[Expression of vascular endothelial growth factor receptors in the ectopic and eutopic endometrium of women with endometriosis] Zhonghua Yi Xue Za Zhi 85 1555-1559
[26]  
Lyttle CR(2009)Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans Fertil. Steril. 91 2199-2209
[27]  
Xiu-li W(2005)Regulation of functional steroid receptors and ligand-induced responses in telomerase-immortalized human endometrial epithelial cells J. Mol. Endocrinol. 34 517-534
[28]  
Wen-jun C(2004)A novel immortalized human endometrial stromal cell line with normal progestational response Endocrinology 145 2291-2296
[29]  
Hui-hua D(2010)Epithelial-stromal interaction and progesterone receptors in the mouse uterus Semin. Reprod. Med. 28 27-35
[30]  
Su-ping H(2008)Tumor necrosis factor-α regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor κB in human endometriotic epithelial cells Mol. Pharmacol. 73 1394-1404
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