A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis

被引：0
作者：
Sang Jun Han
Shannon M Hawkins
Khurshida Begum
Sung Yun Jung
Ertug Kovanci
Jun Qin
John P Lydon
Francesco J DeMayo
Bert W O'Malley
机构：
[1] Baylor College of Medicine,Department of Molecular and Cellular Biology
[2] Baylor College of Medicine,Department of Obstetrics
[3] Baylor College of Medicine,Department of Gynecology
[4] Center for Molecular Discovery,Department of Biochemistry and Molecular Biology
[5] Verna and Marrs McLean,undefined
[6] Baylor College of Medicine,undefined
来源：
Nature Medicine | 2012年 / 18卷
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摘要：
Endometriosis afflicts ~15% of women of reproductive age, causing pelvic pain, and is often associated with infertility. In a new study, Bert O'Malley and his colleagues now show that in response to TNF-α signaling, a unique isoform of SRC-1, an estrogen receptor coactivator, is elevated in endometriotic tissue, preventing the normal apoptosis of these cells. These results could explain the proliferation of these cells, while also further suggesting the antibody to TNF-α etanercept as a therapy for this condition.
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页码：1102 / 1111
页数：9
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