A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis

被引：0
作者：
Sang Jun Han
Shannon M Hawkins
Khurshida Begum
Sung Yun Jung
Ertug Kovanci
Jun Qin
John P Lydon
Francesco J DeMayo
Bert W O'Malley
机构：
[1] Baylor College of Medicine,Department of Molecular and Cellular Biology
[2] Baylor College of Medicine,Department of Obstetrics
[3] Baylor College of Medicine,Department of Gynecology
[4] Center for Molecular Discovery,Department of Biochemistry and Molecular Biology
[5] Verna and Marrs McLean,undefined
[6] Baylor College of Medicine,undefined
来源：
Nature Medicine | 2012年 / 18卷
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摘要：
Endometriosis afflicts ~15% of women of reproductive age, causing pelvic pain, and is often associated with infertility. In a new study, Bert O'Malley and his colleagues now show that in response to TNF-α signaling, a unique isoform of SRC-1, an estrogen receptor coactivator, is elevated in endometriotic tissue, preventing the normal apoptosis of these cells. These results could explain the proliferation of these cells, while also further suggesting the antibody to TNF-α etanercept as a therapy for this condition.
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页码：1102 / 1111
页数：9
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[1]  
Bulun SE(2009)Endometriosis N. Engl. J. Med. 360 268-279
[2]  
Missmer SA(2003)The epidemiology of endometriosis Obstet. Gynecol. Clin. North Am. 30 1-19
[3]  
Cramer DW(1982)“Medical oophorectomy” using a long-acting GNRH agonist—a possible new approach to the treatment of endometriosis J. Clin. Endocrinol. Metab. 54 1081-1083
[4]  
Meldrum DR(1996)Aromatase expression in endometriosis J. Clin. Endocrinol. Metab. 81 174-179
[5]  
Noble LS(2000)Gonadotropin-releasing hormone agonist treatment for endometriosis of the rectovaginal septum Am. J. Obstet. Gynecol. 183 1462-1467
[6]  
Simpson ER(2000)Gonadotropin-releasing hormone analog repairs reduced endometrial cell apoptosis in endometriosis Am. J. Obstet. Gynecol. 182 1142-1146
[7]  
Johns A(2007)Selective estrogen-receptor modulators and aromatase inhibitors: promising new medical therapies for endometriosis? Womens Health (Lond. Engl.) 3 617-628
[8]  
Bulun SE(1999)Expression of oestrogen receptor-α and -β in ovarian endometriomata Mol. Hum. Reprod. 5 742-747
[9]  
Fedele L(2005)A selective estrogen receptor-β agonist causes lesion regression in an experimentally induced model of endometriosis Hum. Reprod. 20 936-941
[10]  
Bianchi S(2009)ERB-041, a selective ER β agonist, inhibits iNOS production in LPS-activated peritoneal macrophages of endometriosis via suppression of NF-κB activation Mol. Immunol. 46 2413-2418
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