Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study

被引:0
作者
Gudrun Rosenberger
Paul G. Nestor
Jungsu S. Oh
James J. Levitt
Gordon Kindleman
Sylvain Bouix
Jennifer Fitzsimmons
Margaret Niznikiewicz
Carl-Fredrik Westin
Ron Kikinis
Robert W. McCarley
Martha E. Shenton
Marek Kubicki
机构
[1] Brigham and Women’s Hospital,Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Radiology
[2] Harvard Medical School,Department of General Psychiatry
[3] Medical University Innsbruck,Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System
[4] Harvard Medical School,Brockton Division, Department of Psychiatry
[5] Department of Nuclear Medicine,Laboratory of Mathematic Imaging, Department of Radiology, Brigham and Women’s Hospital
[6] Asan Medical Center,Psychiatry Neuroimaging Laboratory, Department of Psychiatry
[7] Harvard Medical School,Surgical Planning Laboratory, Department of Radiology, Brigham and Women’s Hospital
[8] Brigham and Women’s Hospital,undefined
[9] Harvard Medical School,undefined
[10] Harvard Medical School,undefined
来源
Brain Imaging and Behavior | 2012年 / 6卷
关键词
Schizophrenia; Disconnection; MRI; Cognitive neuropsychology;
D O I
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中图分类号
学科分类号
摘要
Thalamo-cortical feedback loops play a key role in the processing and coordination of processing and integration of perceptual inputs and outputs, and disruption in this connection has long been hypothesized to contribute significantly to neuropsychological disturbances in schizophrenia. To test this hypothesis, we applied diffusion tensor tractography to 18 patients suffering schizophrenia and 20 control subjects. Fractional anisotropy (FA) was evaluated in the bilateral anterior and posterior limbs of the internal capsule, and correlated with clinical and neurocognitive measures. Patients diagnosed with schizophrenia showed significantly reduced FA bilaterally in the anterior but not the posterior limb of the internal capsule, compared with healthy control subjects. Lower FA correlated with lower scores on tests of declarative episodic memory in the patient group only. These findings suggest that disruptions, bilaterally, in thalamo-cortical connections in schizophrenia may contribute to disease-related impairment in the coordination of mnemonic processes of encoding and retrieval that are vital for efficient learning of new information.
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页码:417 / 425
页数:8
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