miR-202 suppresses proliferation and induces apoptosis of osteosarcoma cells by downregulating Gli2

被引：3
作者：
Zhengwen Sun
Tongqing Zhang
Huanyu Hong
Qingxia Liu
Haiguang Zhang
机构：
[1] Yantaishan Hospital,Department of Traumatology
[2] Yantaishan Hospital,Department of Pediatric Orthopedics
[3] Yantaishan Hospital,Department of Nursing
来源：
Molecular and Cellular Biochemistry | 2014年 / 397卷
关键词：
miR-202; Gli2; Osteosarcoma; Proliferation; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Accumulating data have shown that microRNAs are involved in the pathogenesis of cancer. miR-202 has been confirmed to be downregulated in several types of human cancer. However, the expression and biological role of miR-202 in osteosarcoma (OS) carcinogenesis and progression remain unclear. In this study, we demonstrated that miR-202 expression is significantly decreased in human OS cell lines and specimens. Restoration of miR-202 expression could inhibit OS cell proliferation, induce cell apoptosis, and suppress tumor growth in nude mice models. We subsequently identified the transcription factor Gli2 as a direct target of miR-202. Overexpression of Gli2 blocked the inhibitory function of miR-202. Taken together, our results indicate that miR-202 acts as a novel tumor suppressor to regulate OS cell proliferation and apoptosis through downregulating Gli2 expression.
引用
收藏
页码：277 / 283
页数：6
相关论文
共 213 条
  • [1] Ando K(2013)Current therapeutic strategies and novel approaches in osteosarcoma Cancers (Basel) 5 591-616
  • [2] Heymann MF(2011)The molecular pathogenesis of osteosarcoma: a review Sarcoma 2011 959248-478
  • [3] Stresing V(2009)Current concepts on the molecular biology of osteosarcoma Cancer Treat Res 152 467-441
  • [4] Mori K(2004)Biology and therapeutic advances for pediatric osteosarcoma Oncologist 9 422-1130
  • [5] Redini F(2011)MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression Mol Ther 19 1123-1877
  • [6] Heymann D(2012)miRNA signatures associate with pathogenesis and progression of osteosarcoma Cancer Res 72 1865-179
  • [7] Broadhead ML(2009)MicroRNAs in Cancer Annu Rev Med 60 167-221
  • [8] Clark JC(2008)Control of protein synthesis and mRNA degradation by microRNAs Curr Opin Cell Biol 20 214-355
  • [9] Myers DE(2004)The functions of animal microRNAs Nature 431 350-197
  • [10] Dass CR(2007)A developmental view of microRNA function Trends Biochem Sci 32 189-714
12345678910