Ovarian carcinoma associated with pregnancy: A clinicopathologic analysis of 23 cases and review of the literature

被引：47

作者：

Behtash N. ^{[1
,3
]}

Karimi Zarchi M. ^{[2
]}

Modares Gilani M. ^{[3
]}

Ghaemmaghami F. ^{[3
]}

Mousavi A. ^{[3
]}

Ghotbizadeh F. ^{[3
]}

机构：

[1] Gynecology-Oncology Department, Vali-e-Asr Hospital, Imam Khomeini Hospital, Tehran 14194, Keshavarz Blvd.

[2] Tehran University Of Medical Science, Shahid Sadoughi University of Medical Science, Shahid Sadoughi Hospital, Yazd

[3] Tehran University of Medical Sciences, Tehran

来源：

BMC Pregnancy and Childbirth | / 8卷 / 1期

关键词：

Ovarian Cancer; Germ Cell Tumor; Adnexal Mass; Granulose Cell Tumor; Immature Teratoma;

D O I：

10.1186/1471-2393-8-3

中图分类号：

学科分类号：

摘要：

Background: The aim of this study was to analyze and describe cases of ovarian cancer in pregnant women treated at our center and to review the literature concerned, and to discuss the rationale for therapy. Methods: Twenty-Three patients of ovarian malignancies during pregnancy were treated at Vali- Asr Hospital between 1991 and 2002. Data on treatment and follow-up were evaluated. Results: The incidence of ovarian carcinoma associated with pregnancy in our series was 0.083/1000 deliveries. Eleven (47.8%) were found with ovarian malignant germ cell tumors, five (21.7%) with low malignant potential tumors, four (17.4%) with invasive epithelial tumors, and three (13%) with sex cord stromal tumors. Seventeen (73.9%) of the patients were diagnosed in stage I and had complete remission. Five of the six in advanced stage died. The mean follow-up was 36.3 months. The prognosis was significantly related with stage and histological type (P < 0.05). Sixteen healthy live babies were recorded in this group, and two premature newborn died of respiratory distress syndrome. Chemotherapy was administered to 44% of the patients, in two cases during pregnancy. Overall survival at 5 years was 61%. In most of case conservative surgical treatment could be performed with adequate staging and debulking. Conclusion: Early finding of ascitis by ultrasound and persistent large ovarian mass during pregnancy may be related to malignancy and advanced stage. Pregnant women in advanced stage of ovarian cancer seem to have poor prognosis. © 2008 Behtash et al; licensee BioMed Central Ltd.

引用

共 49 条

[1]

Sayedur Rahman M., Al-Sibai M.H., Rahman J., Ovarian carcinoma associate with pregnancy. A review of 9 cases, Acta Obstet Gynecol Scand, 81, pp. 260-264, (2002)

[2]

Oehler M.K., Wain G.V., Brand A., Gynecological malignancies in pregnancy: A review, Australian and New Zealand Journal of Obstetrics and Gynecology, 43, pp. 414-420, (2003)

[3]

Zhao X.Y., Huang H.F., Lian L.J., Lang J.H., Ovarian cancer in pregnancy: A clinicopathologic analysis of 22 cases and review of the literature, Int J Gynecol Cancer, 16, pp. 8-15, (2006)

[4]

Zanotti K.S., Belinson J.L., Kennedy A.W., Treatment of gynecologic cancers in pregnancy, Semin Oncol, 27, pp. 686-698, (2000)

[5]

Goff B.A., Paley P.J., Koh W.J., Cancer in the pregnant patient, Principles and Practice of Gynecologic Oncology, pp. 501-528, (2000)

[6]

Ueda M., Ueki M., Ovarian tumors associated with pregnancy, Int J Gynaecol Obstet, 55, pp. 59-65, (1996)

[7]

Hermans R.H., Fischer D.C., van der Putten H.W., van de Putte G., Einzmann T., Vos M.C., Kieback D.G., Adnexal masses in pregnancy, Onkologie, 26, pp. 167-172, (2003)

[8]

Takeuchi T., Suzuki S., Hayashi Z., Shinagawa T., Araki T., Primary ovarian tumor undergoing surgical management during pregnancy, J Nippon Med Sch, 69, pp. 39-42, (2002)

[9]

Machado F., Vegas C., Leon J., Perez A., Sanchez R., Parrilla J.J., Abad L., Ovarian cancer during pregnancy: Analysis of 15 cases, Gynecol Oncol, 105, 2, pp. 446-450, (2007)

[10]

Leiserowitz G.S., Xing G., Cress R., Brahmbhatt B., Dalrymple J.L., Smith H., Adnexal masses in pregnancy: How often are they malignant?, Gynecol Oncol 101, pp. 315-321, (2006)

← 1 2 3 4 5 →