An fMRI study of musicians with focal dystonia during tapping tasks

被引:0
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作者
Hiroshi Kadota
Yasoichi Nakajima
Makoto Miyazaki
Hirofumi Sekiguchi
Yutaka Kohno
Masatoshi Amako
Hiroshi Arino
Koichi Nemoto
Naotaka Sakai
机构
[1] National Rehabilitation Center for Persons with Disabilities,Department of Rehabilitation for Sensory Functions, Research Institute
[2] Shibaura Institute of Technology,Course of Functional Control Systems, Graduate School of Engineering
[3] The University of Tokyo,Department of Physical and Health Education, Graduate School of Education
[4] Kochi University of Technology,Research Institute
[5] Jobu University,Faculty of Business and Information Sciences
[6] Ibaraki Prefectural University of Health Sciences,Department of Orthopaedic Surgery
[7] National Defense Medical College,Department of Mechanical and Intelligent Engineering, Graduate School of Engineering
[8] National Defense Medical College Research Institute,Department of Orthopedic Surgery, School of Medicine
[9] National Defense Medical College,undefined
[10] Utsunomiya University,undefined
[11] Yokohama City University,undefined
来源
Journal of Neurology | 2010年 / 257卷
关键词
Functional magnetic resonance imaging; Musician; Dystonia; Premotor cortex;
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摘要
Musician’s dystonia is a type of task specific dystonia for which the pathophysiology is not clear. In this study, we performed functional magnetic resonance imaging to investigate the motor-related brain activity associated with musician’s dystonia. We compared brain activities measured from subjects with focal hand dystonia and normal (control) musicians during right-hand, left-hand, and both-hands tapping tasks. We found activations in the thalamus and the basal ganglia during the tapping tasks in the control group but not in the dystonia group. For both groups, we detected significant activations in the contralateral sensorimotor areas, including the premotor area and cerebellum, during each tapping task. Moreover, direct comparison between the dystonia and control groups showed that the dystonia group had greater activity in the ipsilateral premotor area during the right-hand tapping task and less activity in the left cerebellum during the both-hands tapping task. Thus, the dystonic musicians showed irregular activation patterns in the motor-association system. We suggest that irregular neural activity patterns in dystonic subjects reflect dystonic neural malfunction and consequent compensatory activity to maintain appropriate voluntary movements.
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页码:1092 / 1098
页数:6
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