Upper lip metastasis of sarcomatoid carcinoma of the lung - An unusual site of disease: A case report

被引:3
作者
Le T. [1 ]
Mayer M. [2 ]
Sailors J. [3 ]
Gerber D.E. [1 ,2 ]
Truelson J.M. [2 ,4 ]
机构
[1] Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, 75390, TX
[2] Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, 2201 Inwood Road, Dallas, 75390-9125, TX
[3] Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, 75390, TX
[4] Department of Otolaryngology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, 75390, TX
关键词
Cutaneous; Lip; Lung cancer; Metastasis; Sarcomatoid;
D O I
10.1186/s13256-016-1178-y
中图分类号
学科分类号
摘要
Background: Lip metastases are rare clinical events that are frequently mistaken for other diagnoses. For sarcomatoid lung carcinoma, a rare histologic variant of non-small cell lung cancer, the incidence and pattern of cutaneous spread is poorly understood. Case presentation: We present a case of a 79-year-old African American man with a rapidly progressive upper lip cutaneous lesion that provided the first evidence of distant metastatic spread of sarcomatoid lung carcinoma. Conclusions: This is the first reported case of lip metastasis in sarcomatoid lung carcinoma. It highlights the importance of maintaining a high level of suspicion for metastatic disease in the presence of new cutaneous findings as they may be the first evidence of advanced disease. © 2017 The Author(s).
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共 19 条
[1]  
Travis W.D., Brambilla E., Muller-Hermelink H.K., Harris C.C., World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of the Lung, Pleura, Thymus, and Heart, pp. 53-58, (2004)
[2]  
Travis W.D., Brambilla E., Nicholson A.G., Et al., The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances since the 2004 Classification, J Thorac Oncol, 10, 9, pp. 1243-1260, (2015)
[3]  
Martin L.W., Correa A.M., Ordonez N.G., Et al., Sarcomatoid carcinoma of the lung: A predictor of poor prognosis, Ann Thorac Surg, 84, 3, pp. 973-980, (2007)
[4]  
Venissac N., Pop D., Lassalle S., Berthier F., Hofman P., Mouroux J., Sarcomatoid lung cancer (spindle/giant cells): An aggressive disease?, J Thorac Cardiovasc Surg, 134, 3, pp. 619-623, (2007)
[5]  
Italiano A., Cortot A.B., Ilie M., Et al., EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: Implications for anti-EGFR treatment of a rare lung malignancy, Int J Cancer, 125, 10, pp. 2479-2482, (2009)
[6]  
Jiang X., Liu Y., Chen C., Et al., The value of biomarkers in patients with sarcomatoid carcinoma of the lung: Molecular analysis of 33 cases, Clin Lung Cancer, 13, 4, pp. 288-296, (2012)
[7]  
Nishida K., Kobayashi Y., Ishikawa Y., Et al., Sarcomatoid adenocarcinoma of the lung: Clinicopathological, immunohistochemical and molecular analyses, Anticancer Res, 22, 6 B, pp. 3477-3483, (2002)
[8]  
Nakajima M., Kasai T., Hashimoto H., Iwata Y., Manabe H., Sarcomatoid carcinoma of the lung: A clinicopathologic study of 37 cases, Cancer, 86, 4, pp. 608-616, (1999)
[9]  
Chang Y.L., Lee Y.C., Shih J.Y., Wu C.T., Pulmonary pleomorphic (spindle) cell carcinoma: Peculiar clinicopathologic manifestations different from ordinary non-small cell carcinoma, Lung Cancer, 34, 1, pp. 91-97, (2001)
[10]  
Park J.S., Lee Y., Han J., Et al., Clinicopathologic outcomes of curative resection for sarcomatoid carcinoma of the lung, Oncology, 81, 3-4, pp. 206-213, (2011)