p53 and little brother p53/47: linking IRES activities with protein functions

被引：0
作者：
R Grover
M M Candeias
R Fåhraeus
S Das
机构：
[1] Indian Institute of Science,Department of Microbiology and Cell Biology
[2] Inserm U716,undefined
[3] Pharmacologie Expérimentale,undefined
[4] Institut Génétique Moléculaire,undefined
[5] Hôpital St Louis and Université Paris 7,undefined
[6] 4Current address: Institute of Bioinformatics and Applied Biotechnology,undefined
[7] Bangalore,undefined
[8] India.,undefined
[9] 5Current address: Department of Clinical Molecular Biology,undefined
[10] Graduate School of Medicine Kyoto University,undefined
[11] Kyoto 606-8507,undefined
[12] Japan.,undefined
来源：
Oncogene | 2009年 / 28卷
关键词：
p53; p53/47; IRES; translational control;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The tumor suppressor p53 represents a paradigm for gene regulation. Its rapid induction in response to DNA damage conditions has been attributed to both increased half-life of p53 protein and also increased translation of p53 mRNA. Recent advances in our understanding of the post-transcriptional regulation of p53 include the discovery of internal ribosome entry sites (IRESs) within the p53 mRNA. These IRES elements regulate the translation of the full length as well as the N-terminally truncated isoform, p53/47. The p53/47 isoform is generated by alternative initiation at an internal AUG codon present within the p53 ORF. The aim of this review is to summarize the role of translational control mechanisms in regulating p53 functions. We discuss here in detail how diverse cellular stress pathways trigger alterations in the cap-dependent and cap-independent translation of p53 mRNA and how changes in the relative expression levels of p53 isoforms result in more differentiated p53 activity.
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页码：2766 / 2772
页数：6
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  • [1] Anensen N(2006)Acute myelogenous leukemia in a patient with Li-Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report Leukemia 20 734-736
  • [2] Skavland J(2006)Searching for IRES RNA 12 1755-1785
  • [3] Stapnes C(1993)mdm2 expression is induced by wild type p53 activity EMBO J 12 461-468
  • [4] Ryningen A(2007)Expression of p53 isoforms in squamous cell carcinoma of the head and neck Eur J Cancer 43 617-623
  • [5] Borresen-Dale AL(2007)p53 and its isoforms in cancer Br J Cancer 97 277-282
  • [6] Gjertsen BT(2005)p53 isoforms can regulate p53 transcriptional activity Genes Dev 19 2122-2137
  • [7] Baird SD(2006)Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis Mol Cell 23 401-412
  • [8] Turcotte M(2006)Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation Oncogene 25 6936-6947
  • [9] Korneluk RG(2008)p53 mRNA controls p53 activity by managing Mdm2 functions Nat Cell Biol 10 1098-1105
  • [10] Holcik M(2001)Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins J Cell Mol Med 5 221-239
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