Development of a peptide-containing chewing gum as a sustained release antiplaque antimicrobial delivery system

被引：0
作者：
Jabar A. Faraj
Rossella Dorati
Aurélie Schoubben
David Worthen
Francesca Selmin
Yilmaz Capan
Kai Leung
Patrick P. DeLuca
机构：
[1] University of Kentucky College of Pharmacy,Faculty of Pharmaceutical Sciences
[2] University of Pavia,Department of Medicinal Chemistry
[3] University of Perugia,Department of Chemistry and Technology of Drugs
[4] Institute of Medicinal Chemistry and Toxicology University of Milan,Department of Pharmaceutical Technology, Faculty of Pharmacy
[5] Hacettepe University,Microbiology Branch, US Army Dental and Trauma Research Detachment
[6] Walter Reed Army Institute of Research,undefined
来源：
AAPS PharmSciTech | / 8卷
关键词：
KSL-W; chewing gum; sustained release; cetylpyridinium chloride; antiplaque; antimicrobial; peptide; stability;
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摘要：
The objective of this study was to characterize the stability of KSL-W, an antimicrobial decapeptide shown to inhibit the growth of oral bacterial strains associated with caries development and plaque formation, and its potential as an antiplaque agent in a chewing gum formulation. KSL-W formulations with or without the commercial antibacterial agent cetylpyridinium chloride (CPC) were prepared. The release of KSL-W from the gums was assessed in vitro using a chewing gum apparatus and in vivo by a chew-out method. A reverse-phase high-performance liquid chromatography method was developed for assaying KSL-W. Raw material stability and temperature and pH effects on the stability of KSL-W solutions and interactions of KSL-W with tooth-like material, hydroxyapatite discs, were investigated.
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