1H, 13C, and 15N resonance assignments for the pro-inflammatory cytokine interleukin-36α

被引：0

作者：

Nishit Goradia

Amelie Wißbrock

Christoph Wiedemann

Frank Bordusa

Ramadurai Ramachandran

Diana Imhof

Oliver Ohlenschläger

机构：

[1] Leibniz Institute on Aging – Fritz Lipmann Institute,Institute of Biochemistry/Biotechnology

[2] Martin Luther University Halle-Wittenberg,Pharmaceutical Chemistry I, Institute of Pharmacy

[3] University of Bonn,undefined

来源：

Biomolecular NMR Assignments | 2016年 / 10卷

关键词：

Backbone resonance assignments; Heteronuclear NMR; Interleukin-36α; Interleukin-1 superfamily; Cytokine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Interleukin-36α (IL-36α) is a recently characterised member of the interleukin-1 superfamily. It is involved in the pathogenesis of inflammatory arthritis in one third of psoriasis patients. By binding of IL-36α to its receptor IL-36R via the NF-κB pathway other cytokines involved in inflammatory and apoptotic cascade are activated. The efficacy of complex formation is controlled by N-terminal processing. To obtain a more detailed view on the structure function relationship we performed a heteronuclear multidimensional NMR investigation and here report the 1H, 13C, and 15N resonance assignments for the backbone and side chain nuclei of the pro-inflammatory cytokine interleukin-36α.

引用

页码：329 / 333

页数：4

共 49 条

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