Pathophysiology and treatment options for cardiac anorexia

被引:10
作者
Fudim M. [1 ]
Wagman G. [2 ]
Altschul R. [3 ]
Yucel E. [4 ]
Bloom M. [2 ]
Vittorio T.J. [2 ]
机构
[1] Heinrich-Heine-Universität, Düsseldorf
[2] Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, NY 10029-6574
[3] Department of Medicine, Mount Sinai School of Medicine, New York, NY
[4] Department of Medicine, State University of New York at Brooklyn, Brooklyn, NY
关键词
Anorexia; Cachexia; Chronic heart failure; Neurohormonal;
D O I
10.1007/s11897-011-0049-5
中图分类号
学科分类号
摘要
The anorexia-cachexia syndrome (ACS) occurs in many chronic illnesses, such as cancer, AIDS, and chronic obstructive pulmonary disease in addition to chronic congestive heart failure (CHF). Comparable to other chronic states, the ACS complicates CHF and impacts its prognosis; however, the available treatment options for this syndrome remain unsatisfactory. This review article focuses on the complex pathophysiology of cardiac anorexia. We focus on the recent data demonstrating the relationships between central appetite-regulating structures, inflammatory processes, and neurohormonal activation, and their respective roles in the development of anorexia. We then describe the different treatment options and discuss some future prospects for the management for cardiac anorexia. © 2011 Springer Science+Business Media, LLC.
引用
收藏
页码:147 / 153
页数:6
相关论文
共 87 条
  • [1] Lloyd-Jones D.M., Larson M.G., Leip E.P., Beiser A., D'Agostino R.B., Kannel W.B., Murabito J.M., Vasan R.S., Benjamin E.J., Levy D., Lifetime risk for developing congestive heart failure: The Framingham Heart Study, Circulation, 106, 24, pp. 3068-3072, (2002)
  • [2] Rosamond W., Flegal K., Friday G., Et al., Heart disease and stroke statistics-2007 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Circulation, 115, 5, (2007)
  • [3] Roger V.L., Weston S.A., Redfield M.M., Hellermann-Homan J.P., Killian J., Yawn B.P., Jacobsen S.J., Trends in heart failure incidence and survival in a community-based population, Journal of the American Medical Association, 292, 3, pp. 344-350, (2004)
  • [4] Bleumink G.S., Knetsch A.M., Sturkenboom M.C.J.M., Straus S.M.J.M., Hofman A., Deckers J.W., Witteman J.C.M., Stricker B.H.Ch., Quantifying the heart failure epidemic: Prevalence, incidence rate, lifetime risk and prognosis of heart failure - The Rotterdam Study, European Heart Journal, 25, 18, pp. 1614-1619, (2004)
  • [5] Stephens N.A., Fearon K.C.H., Anorexia, cachexia and nutrition, Medicine, 36, 2, pp. 78-81, (2008)
  • [6] Von Haehling S., Lainscak M., Springer J., Et al., Cardiac cachexia: A systematic overview, Pharmacol Ther, 121, 3, pp. 227-252, (2009)
  • [7] Muscaritoli M., Anker S.D., Argiles J., Et al., Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics, Clin Nutr, 29, 2, pp. 154-159, (2010)
  • [8] Maltoni M., Pirovano M., Scarpi E., Et al., Prediction of survival of patients terminally ill with cancer. Results of an Italian prospective multicentric study, Cancer, 75, 10, pp. 2613-2622, (1995)
  • [9] Kalantar-Zadeh K., Block G., McAllister C.J., Humphreys M.H., Kopple J.D., Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients, American Journal of Clinical Nutrition, 80, 2, pp. 299-307, (2004)
  • [10] Anker S.D., Ponikowski P., Varney S., Et al., Wasting as independent risk factor for mortality in chronic heart failure, Lancet, 349, (1997)