The miR-15a–miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities

被引：0
|
作者：
Désirée Bonci
Valeria Coppola
Maria Musumeci
Antonio Addario
Raffaella Giuffrida
Lorenzo Memeo
Leonardo D'Urso
Alfredo Pagliuca
Mauro Biffoni
Catherine Labbaye
Monica Bartucci
Giovanni Muto
Cesare Peschle
Ruggero De Maria
机构：
[1] Oncology and Molecular Medicine,Department of Hematology
[2] Istituto Superiore Sanità,Department of Experimental Oncology
[3] viale Regina Elena 299,Department of Urology
[4] Mediterranean Institute of Oncology,undefined
[5] via Penninazzo 7,undefined
[6] San Giovanni Bosco Hospital,undefined
[7] piazza Donatori del sangue 3,undefined
[8] Istituto di Ricovero e Cura a Carattere Scientifico,undefined
[9] MultiMedica,undefined
[10] via Fantoli 16/15,undefined
来源：
Nature Medicine | 2008年 / 14卷
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学科分类号：
摘要：
Two microRNAs, miR-15a and miR-16, localize to a chromosome region that is frequently deleted in cancer. Bonci et al. now show that these microRNAs have tumor suppressive effects in prostate cancer cells and regulate the expression of crucial oncogenic targets.
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页码：1271 / 1277
页数：6
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