Relationships between inflammatory mediators and coronary plaque composition in patients with stable angina investigated by ultrasound radiofrequency data analysis

被引：2
作者：
Satoh S. [1 ]
Mori E. [1 ]
Takenaka K. [1 ]
Mori T. [1 ]
Inoue H. [1 ]
Numaguchi K. [1 ]
Hiyamuta K. [1 ]
机构：
[1] Department of Cardiology and Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, 810-8563, 1-8-1 Jigyohama, Chuo-ku
来源：
Cardiovascular Intervention and Therapeutics | 2011年 / 26卷 / 3期
关键词：
Coronary artery disease; Inflammation; Intravascular ultrasound; Plaque;
D O I：
10.1007/s12928-011-0058-z
中图分类号：
学科分类号：
摘要：
Inflammation has been recognized as a critical process in the progression of coronary atherosclerosis. Virtual Histology-intravascular ultrasound (VH-IVUS) has been reported to be a useful tool for tissue characterization of coronary atherosclerotic plaque. We investigated relationships between plaque composition and inflammation-related factors possibly contributing to atheromatous plaque formation and progression, since these are largely unknown. Using VH-IVUS, we measured plaque volume and composition at the culprit lesions in patients with stable angina undergoing elective percutaneous coronary intervention (n = 33, 39 de novo lesions), and then analyzed correlations between plaque components and serum levels of inflammatory factors in both aorta and culprit coronary artery obtained by aspiration using a distal protection device. Linear regression analysis revealed that both aortic and coronary LDL cholesterol levels correlated with %plaque burden along the culprit lesions (r = 0. 535 and 0. 539, respectively), but with none of the plaque components. Of %plaque components, fibro-fatty (FF) correlated positively with both aortic and coronary T cell/B cell ratios (r = 0. 335 and 0. 359, respectively) whereas necrotic core (NC) correlated negatively with both aortic and coronary T cell/B cell ratios (r = -0. 373 and -0. 483, respectively). These results suggest that LDL cholesterol may be a good marker for total coronary plaque volume whereas the lymphocyte subset of T cell/B cell ratios may be a good marker for plaque composition, especially FF and NC components volume. © 2011 Japanese Association of Cardiovascular Intervention and Therapeutics.
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页码：193 / 201
页数：8
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