β2-Adrenergic Receptor Haplotype may be Associated with Susceptibility to Desensitization to Long-Acting β2-Agonists in COPD Patients

[1] Taylor DR(2007)beta-Adrenergic receptor polymorphisms: relationship to the beta-agonist controversy and clinical implications Expert Opin Pharmacother 18 3195-3203

[2] Cazzola M(2011)β2-adrenoceptor agonists: current and future direction Br J Pharmacol 163 4-17

[3] Calzetta L(2000)Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness Proc Natl Acad Sci USA 97 10483-10488

[4] Matera MG(2006)Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study Am J Respir Crit Care Med 174 1101-1109

[5] Drysdale CM(2010)Common ADRB2 haplotypes derived from 26 polymorphic sites direct β2-adrenergic receptor expression and regulation phenotypes PLoS One 5 e11819-9419

[6] McGraw DW(1994)Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties Biochemistry 33 9414-1932

[7] Stack CB(1998)Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression J Clin Invest 102 1927-1035

[8] Stephens JC(2001)The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization N Engl J Med 345 1030-1641

[9] Judson RS(1995)Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype J Clin Invest 95 1635-3188

[10] Nandabalan K(1997)Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing J Clin Invest 100 3184-80

[1] Taylor DR(2007)beta-Adrenergic receptor polymorphisms: relationship to the beta-agonist controversy and clinical implications Expert Opin Pharmacother 18 3195-3203

[2] Cazzola M(2011)β2-adrenoceptor agonists: current and future direction Br J Pharmacol 163 4-17

[3] Calzetta L(2000)Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness Proc Natl Acad Sci USA 97 10483-10488

[4] Matera MG(2006)Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study Am J Respir Crit Care Med 174 1101-1109

[5] Drysdale CM(2010)Common ADRB2 haplotypes derived from 26 polymorphic sites direct β2-adrenergic receptor expression and regulation phenotypes PLoS One 5 e11819-9419

[6] McGraw DW(1994)Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties Biochemistry 33 9414-1932

[7] Stack CB(1998)Polymorphisms of the 5′ leader cistron of the human beta2-adrenergic receptor regulate receptor expression J Clin Invest 102 1927-1035

[8] Stephens JC(2001)The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization N Engl J Med 345 1030-1641

[9] Judson RS(1995)Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype J Clin Invest 95 1635-3188

[10] Nandabalan K(1997)Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing J Clin Invest 100 3184-80