Review on two-dimensional material-based field-effect transistor biosensors: accomplishments, mechanisms, and perspectives

被引：0
作者：
Shuo Chen
Yang Sun
Xiangyu Fan
Yazhe Xu
Shanshan Chen
Xinhao Zhang
Baoyuan Man
Cheng Yang
Jun Du
机构：
[1] Shandong Normal University,School of Physics and Electronics
[2] University of Science and Technology,Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering
来源：
Journal of Nanobiotechnology | / 21卷
关键词：
Two-Dimensional Material; Field-effect transistor; Biosensor; Biomarker detection; Sensing application;
D O I：
暂无
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学科分类号：
摘要：
Field-effect transistor (FET) is regarded as the most promising candidate for the next-generation biosensor, benefiting from the advantages of label-free, easy operation, low cost, easy integration, and direct detection of biomarkers in liquid environments. With the burgeoning advances in nanotechnology and biotechnology, researchers are trying to improve the sensitivity of FET biosensors and broaden their application scenarios from multiple strategies. In order to enable researchers to understand and apply FET biosensors deeply, focusing on the multidisciplinary technical details, the iteration and evolution of FET biosensors are reviewed from exploring the sensing mechanism in detecting biomolecules (research direction 1), the response signal type (research direction 2), the sensing performance optimization (research direction 3), and the integration strategy (research direction 4). Aiming at each research direction, forward perspectives and dialectical evaluations are summarized to enlighten rewarding investigations.
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[1]  
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Wang X(2021)Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor Nat Biomed Eng 5 713-725
[3]  
Wu Y(2019)Detection of unamplified target genes via CRISPR–Cas9 immobilized on a graphene field-effect transistor Nat Biomed Eng 3 427-437
[4]  
Guo M(2020)Ultrasensitive detection of nucleic acids using deformed graphene channel field effect biosensors Nat Commun 11 1-11
[5]  
Gu C(2017)Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor Nat Commun 8 1-10
[6]  
Dai C(2019)Specific and label-free immunosensing of protein-protein interactions with silicon-based immunoFETs Biosens Bioelectron 132 143-161
[7]  
Kong D(2022)Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring Sci Adv 8 eabk0967-110
[8]  
Wang Y(2018)Cascading reaction of arginase and urease on a graphene-based FET for ultrasensitive, real-time detection of arginine Biosens Bioelectron 115 104-1077
[9]  
Zhang C(2020)Non-enzymatic and highly sensitive lactose detection utilizing graphene field-effect transistors Biosens Bioelectron 165 1065-13
[10]  
Qu D(2022)Recent advances in carbon nanotube-based biosensors for biomolecular detection TrAC TrendS Anal Chem 154 6-3031
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