Prophylaxis and treatment of GVHD: EBMT–ELN working group recommendations for a standardized practice

被引：0

作者：

T Ruutu

A Gratwohl

T de Witte

B Afanasyev

J Apperley

A Bacigalupo

F Dazzi

P Dreger

R Duarte

J Finke

L Garderet

H Greinix

E Holler

N Kröger

A Lawitschka

M Mohty

A Nagler

J Passweg

O Ringdén

G Socié

J Sierra

A Sureda

W Wiktor-Jedrzejczak

A Madrigal

D Niederwieser

机构：

[1] Helsinki University Central Hospital,Department of Medicine

[2] Hematology,Department of Tumor Immunology

[3] Medical Faculty,Department of Haematology

[4] University of Basel,Division of Hematology

[5] Nijmegen Centre for Molecular Life Sciences,Department of Medicine

[6] Radboud University Nijmegen Medical Centre,Department of Medicine V

[7] R. Gorbacheva Memorial Institute of Oncology,Department of Hematology

[8] Hematology and Transplantation,Department of Internal Medicine I

[9] St Petersburg State Medical I.P.Pavlov University,Department of Haematology/Oncology

[10] Hammersmith Hospital,Department of Stem Cell Transplantation

[11] Imperial College London,Hematology Division

[12] IRCCS San Martino,Department of Hematology—Transplantation

[13] Imperial College London,Haematology Department

[14] Hammersmith Campus,Department of Hematology

[15] University of Heidelberg,Department of Hematology/Oncology and Hemostasiology

[16] Institut Català d’Oncologia,undefined

[17] L’Hospitalet de Llobregat,undefined

[18] Oncology and Stem Cell Transplantation,undefined

[19] University Medical Center,undefined

[20] Service d’Hematologie,undefined

[21] Hôpital Saint Antoine,undefined

[22] Medical University,undefined

[23] University Hospital Regensburg,undefined

[24] University Cancer Centre Hamburg,undefined

[25] St Anna Children’s Hospital,undefined

[26] Service d’Hématologie Clinique et de Thérapie Cellulaire,undefined

[27] Hopital Saint Antoine,undefined

[28] Universite Pierre et Marie Curie,undefined

[29] INSERM,undefined

[30] Tel-Aviv University,undefined

[31] Sheba Medical Center,undefined

[32] Center for Stem Cell Transplantation,undefined

[33] University Hospital Basel,undefined

[34] Center for Allogeneic Stem Cell Transplantation,undefined

[35] Karolinska Institute,undefined

[36] Karolinska University Hospital,undefined

[37] Saint-Louis Hospital,undefined

[38] Haematology Service,undefined

[39] Hospital de la Santa Creu i Sant Pau,undefined

[40] Addenbrookes Hospital,undefined

[41] Oncology and Internal Diseases,undefined

[42] Medical University of Warsaw,undefined

[43] Anthony Nolan Research Institute,undefined

[44] Royal Free Hospital,undefined

[45] University of Leipzig,undefined

来源：

Bone Marrow Transplantation | 2014年 / 49卷

关键词：

GVHD; prophylaxis; treatment;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

GVHD remains the major impediment to broader application of allogeneic haematopoietic SCT. It can be prevented completely, but at the expense of other complications, rejection, relapse or delayed immune reconstitution. No optimal prevention or treatment method has been defined. This is reflected by enormous heterogeneity in approaches in Europe. Retrospective comparisons between different policies, although warranted, do not give definite answers. In order to improve the present situation, an European Group for Blood and Marrow Transplantation and the European LeukemiaNet working group has developed in a Delphi-like approach recommendations for prophylaxis and treatment of GVHD in the most common allogeneic transplant setting, transplantation from an HLA-identical sibling or unrelated donor for standard risk malignant disease. The working group proposes these guidelines to be adopted as routine standard in transplantation centres and to be used as comparator in systematic studies evaluating the advantages and disadvantages of practices differing from these recommendations.

引用

页码：168 / 173

页数：5

共 14 条

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