Base excision repair and the role of MUTYH

被引：0

作者：

Carla Kairupan

Rodney J. Scott

机构：

[1] University of Newcastle,Discipline of Medical Genetics, School of Biomedical Science, Faculty of Health

[2] and the Hunter Medical Research Institute,Division of Genetics, Hunter Area Pathology Service

[3] John Hunter Hospital,undefined

来源：

Hereditary Cancer in Clinical Practice | / 5卷

关键词：

base excision repair; DNA repair; mutations;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development. The mechanisms underlying the process of base excision repair are relatively well understood and are placed in context with how deterioration of this process is associated with an increased risk of malignancy.

引用

共 50 条

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Kairupan, Carla
Scott, Rodney J.
HEREDITARY CANCER IN CLINICAL PRACTICE, 2007, 5 (04) : 199 - 209
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Kuno, Takashi
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ONCOLOGY REPORTS, 2012, 28 (02) : 473 - 480
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NUCLEIC ACIDS RESEARCH, 2021, 49 (12) : 7154 - 7163
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[5] The Mutyh Base Excision Repair Gene Influences the Inflammatory Response in a Mouse Model of Ulcerative Colitis
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PLOS ONE, 2010, 5 (08):
[6] MUTYH-associated polyposis- : From defect in base excision repair to clinical genetic testing
Cheadle, Jeremy P.
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DNA REPAIR, 2007, 6 (03) : 274 - 279
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Oka, Sugako
Sheng Zijing
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GENES & GENETIC SYSTEMS, 2014, 89 (06) : 279 - 279
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Zhou, JM
Ahn, J
Wilson, SH
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EMBO JOURNAL, 2001, 20 (04): : 914 - 923
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Burgis, NE
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GENOME INSTABILITY IN CANCER DEVELOPMENT, 2005, 570 : 125 - 173

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