Base excision repair and the role of MUTYH

被引：0
作者：
Carla Kairupan
Rodney J. Scott
机构：
[1] University of Newcastle,Discipline of Medical Genetics, School of Biomedical Science, Faculty of Health
[2] and the Hunter Medical Research Institute,Division of Genetics, Hunter Area Pathology Service
[3] John Hunter Hospital,undefined
来源：
Hereditary Cancer in Clinical Practice | / 5卷
关键词：
base excision repair; DNA repair; mutations;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The correction of exogenous and endogenous environmental insult to DNA involves a series of DNA repair mechanisms that reduce the likelihood of mutation accumulation and hence an increased probability of tumour development. The mechanisms underlying the process of base excision repair are relatively well understood and are placed in context with how deterioration of this process is associated with an increased risk of malignancy.
引用
收藏
相关论文
共 611 条
[1]  
Lindahl T(1999)Quality control by DNA repair Science 286 1897-1905
[2]  
Wood RD(1986)Mutagenesis by apurinic/apyrimidinic sites Annu Rev Genet 20 201-230
[3]  
Loeb L(1990)The abasic site as a challenge to DNA polymerase. A nuclear magnetic resonance study of G, C and T opposite a model abasic site J Mol Biol 213 303-314
[4]  
Preston BD(1994)Repair of oxidative damage to DNA: enzymology and biology Annu Rev Biochem 63 9315-9348
[5]  
Cuniasse P(1996)DNA repair in eukaryotes Annu Rev Biochem 65 135-167
[6]  
Fazakerly GV(2003)An evolutionary analysis of the helix-hairpin-helix superfamily of DNA repair glycosylases Mol Biol Evol 20 1603-1611
[7]  
Guschlbauer W(1997)DNA glycosylases in the base excision repair of DNA Biochem J 325 1-16
[8]  
Kaplan B(1999)3-methyladenine DNA glycosylases: structure, function, and biological importance Bioessays 21 668-676
[9]  
Sowers LC(1999)DNA repair mechanisms for the recognition and removal of damaged DNA bases Annu Rev Biophys Biomol Struct 28 101-128
[10]  
Demple B(2000)Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA Nature 403 859-866
12345678910