The action and mechanism of myrislignan on A549 cells in vitro and in vivo

被引：0
作者：
XinGang Lu
Liu Yang
JingXian Chen
JiAn Zhou
XiaoDan Tang
YingGang Zhu
HongFu Qiu
Jie Shen
机构：
[1] FuDan University,Department of Traditional Chinese Medicine, HuaDong Hospital
[2] BaoShan Hospital of Integrated Traditional Chinese and Western Medicine,Department of Tumor
[3] JiaoTong University School of Medicine,Department of Traditional Chinese Medicine, RuiJin Hospital
[4] FuDan University,Department of Pulmonary, HuaDong Hospital
[5] FuDan University,Department of Pharmacy, HuaDong Hospital
来源：
Journal of Natural Medicines | 2017年 / 71卷
关键词：
Human lung cancer cells; Apoptosis; Cell cycle arrest; Myrislignan; EGFR-MAPK;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Myrislignan is a natural compound with little pharmacological study. In our investigation, we investigated the effect of myrislignan in the induction of apoptosis in A549 cells in vitro and in vivo. Myrislignan inhibited the proliferation of A549 cells in a dose- and time-dependent manner assayed by MTT. In addition, Hoechst flow cytometry showed that myrislignan significantly induced apoptosis and cell cycle arrest in A549 cells. The apoptosis and anti-cell proliferation was mediated by the activation of mitogen-activated protein kinase and the inhibition of epidermal growth factor receptor signal pathway, change of mitochondrial membrane potential, the releasing of c-Myc, the downregulation of the level of the anti-apoptotic protein Bcl-2, and the upregulation of the level of the pro-apoptotic protein Bax. In conclusion, those results reveal a potential mechanism for the anti-cancer effect of myrislignan on human lung cancer, while suggesting that myrislignan may be a promising compound for the treatment of lung cancer.
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页码：76 / 85
页数：9
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