Complex Formation of Cyclodextrins with Sulfasalazine in Buffer Solutions

被引：0
作者：
D. Yu. Kuranov
E. S. Chibunova
T. V. Volkova
I. V. Terekhova
机构：
[1] Russian Academy of Sciences,G.A. Krestov Institute of Solution Chemistry
来源：
Russian Journal of General Chemistry | 2018年 / 88卷
关键词：
cyclodextrins; sulfasalazine; complex formation; thermodynamics; solubility;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Complex formation of α-, β-, and γ-cyclodextrins with sulfasalazine in biologically relevant buffer solutions (pH 1.2 and 7.4) was studied. Formation of inclusion complexes of 1 : 1 stoichiometry between the drug and cyclodextrins was revealed. The ionization state of sulfasalazine more strongly affects the complex formation than does the structure of cyclodextrins. Compared with a neutral molecule, sulfasalazine anionic species forms with cyclodextrins more stable complexes, which are essentially stabilized by possible surface interactions.
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页码：1325 / 1330
页数：5
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