Functional significance of Ca2+ in long-lasting fatigue of skeletal muscle

被引:0
作者
Håkan Westerblad
Joseph D. Bruton
David G. Allen
Jan Lännergren
机构
[1] Department of Physiology and Pharmacology,
[2] Karolinska Institutet,undefined
[3] 171 77 Stockholm,undefined
[4] Sweden e-mail: hakan.westerblad@fyfa.ki.se Fax: +46-8-327026,undefined
[5] Department of Physiology F13,undefined
[6] Institute for Biomedical Science,undefined
[7] University of Sydney,undefined
[8] NSW 2006,undefined
[9] Australia,undefined
来源
European Journal of Applied Physiology | 2000年 / 83卷
关键词
Key words Fatigue; Skeletal muscle; Calcium; Sarcoplasmic reticulum;
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中图分类号
学科分类号
摘要
Repeated activation of skeletal muscle causes fatigue, which involves a reduced ability to produce force and slowed contraction regarding both the speed of shortening and relaxation. One important component in skeletal muscle fatigue is a reduced sarcoplasmic reticulum (SR) Ca2+ release. In the present review we will describe different types of fatigue-induced inhibition of SR Ca2+ release. We will focus on a type of long-lasting failure of SR Ca2+ release which is called low-frequency fatigue, because this type of fatigue may be involved in the muscle dysfunction and chronic pain experienced by computer workers. Paradoxically it appears that the Ca2+ released from the SR, which is required for contraction, may actually be responsible for the failure of SR Ca2+ release during low-frequency fatigue. We will also discuss the relationship between gross morphological changes in muscle fibres and long-lasting failure of SR Ca2+ release. Finally, a model linking muscle cell dysfunction and muscle pain is proposed.
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页码:166 / 174
页数:8
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