Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: study protocol for a pilot randomized controlled trial, the PROTECTION trial

被引：0

作者：

Tommaso Mauri

Giuseppe Foti

Carla Fornari

Jean-Michel Constantin

Claude Guerin

Paolo Pelosi

Marco Ranieri

Sara Conti

Daniela Tubiolo

Egle Rondelli

Federica Lovisari

Tommaso Fossali

Savino Spadaro

Domenico Luca Grieco

Paolo Navalesi

Italo Calamai

Tobias Becher

Oriol Roca

Yu-Mei Wang

Rihard Knafelj

Andrea Cortegiani

Jordi Mancebo

Laurent Brochard

Antonio Pesenti

机构：

[1] University of Milan,Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico

[2] University of Milan-Bicocca,ASST Monza

[3] University of Milan-Bicocca,Research Centre on Public Health, School of Medicine and Surgery

[4] University Hospital of Clermont-Ferrand,Department of Preoperative Medicine

[5] Hôpital de la Croix Rousse,Service de Réanimation Médicale

[6] San Martino Policlinico Hospital,Department of Surgical and Integrated Diagnostics

[7] IRCCS for Oncology,Department of Anesthesia and Intensive Care Medicine

[8] University of Genoa,Department of Anesthesia and Critical Care

[9] Sapienza University of Rome,Department of Anesthesiology and Intensive Care

[10] Niguarda Hospital,Department of morphology, surgery and experimental medicine

[11] University of Milan-Bicocca,Department of Anesthesiology and Intensive Care Medicine

[12] ASST Fatebenefratelli Sacco - Luigi Sacco Hospital,Dipartimento di Scienze Mediche e Chirurgiche

[13] Azienda Ospedaliera-Universitaria Arcispedale Sant’Anna,AUSL Toscana Centro, Unit of Anesthesia and Resuscitation

[14] Catholic University of The Sacred Heart,Department of Anesthesiology and Intensive Care Medicine

[15] IRCCS Fondazione Policlinico A. Gemelli,Critical Care Department

[16] Università Magna Graecia di Catanzaro,Department of Critical Care Medicine

[17] Azienda Ospedaliera Universitaria Mater Domini,Center for Internal Intensive medicine (MICU)

[18] San Giuseppe Hospital,Department of Biopathology and Medical Biotechnologies (DIBIMED), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone

[19] University Medical Center Schleswig-Holstein,Servei de Medicina Intensiva

[20] Vall d’Hebron University Hospital,Interdepartmental Division of Critical Care Medicine

[21] Vall d’Hebron Research Institute,Keenan Research Centre, Li Ka Shing Knowledge Institute

[22] Universitat Autònoma de Barcelona,Department of Anesthesiology, Intensive Care and Transplants

[23] Beijing Tiantan Hospital,Département de Médecine Intensive

[24] Capital Medical University, Réanimation, CHU d’Angers

[25] University Medical Center Ljubljana,Department of Intensive Care Medicine

[26] University of Palermo,Intensive Care Unit

[27] Hospital de la Santa Creu i Sant Pau,Anesthesia and Critical Care, Department of Pathophysiology and Transplantation

[28] Universitat Autònoma de Barcelona (UAB),undefined

[29] University of Toronto,undefined

[30] St. Michael’s Hospital,undefined

[31] Istituto Clinico Humanitas,undefined

[32] University Hospital St. Orsola-Malpighi,undefined

[33] Université d’Angers,undefined

[34] Sud Ile-de-France Hospitals,undefined

[35] BHR University Hospitals NHS Trust,undefined

[36] Hospital Universitario Fundación Jiménez Díaz de Madrid,undefined

[37] Larissa General Hospital,undefined

[38] University of Milan,undefined

[39] Department of Anesthesia,undefined

[40] Critical Care and Emergency,undefined

[41] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,undefined

来源：

Trials | / 19卷

关键词：

Mechanical ventilation; Intervention study; Ventilator-induced lung injury; Positive-pressure ventilation; Sigh; Recruitment; Weaning; Pressure support;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 138 条

[1] Slutsky AS(2013)Ventilator-induced lung injury N Engl J Med 369 2126-2136
[2] Ranieri VM(2000)Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome N Engl J Med 342 1301-1308
[3] Brower RG(2017)An official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine clinical practice guideline: mechanical ventilation in adult patients with acute respiratory distress syndrome Am J Respir Crit Care Med 195 1253-1263
[4] Matthay MA(2016)Do spontaneous and mechanical breathing have similar effects on average transpulmonary and alveolar pressure? A clinical crossover study Crit Care 20 142-800
[5] Morris A(2017)Spontaneous breathing: a double-edged sword to handle with care Ann Transl Med 5 292-608
[6] Schoenfeld D(2016)Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries JAMA 315 788-1199
[7] Thompson BT(1970)Stress distribution in lungs: a model of pulmonary elasticity J Appl Physiol 28 596-1296
[8] Wheeler A(2011)Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury Am J Respir Crit Care Med 183 1193-545
[9] Fan E(2018)High positive end-expiratory pressure renders spontaneous effort noninjurious Am J Respir Crit Care Med 197 1285-507
[10] Del Sorbo L(2013)The comparison of spontaneous breathing and muscle paralysis in two different severities of experimental lung injury Crit Care Med 41 536-794

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