Roles of the matrix metalloproteinases in mammary gland development and cancer

被引：0
作者：
Christelle Benaud
Robert B. Dickson
Erik W. Thompson
机构：
[1] Vincent T. Lombardi Cancer Center,Departments of Cell Biology
[2] Pharmacology,Orthopedic Surgery
[3] Georgetown University Medical Center,VBCRC Breast Cancer Research Unit
[4] NW,undefined
[5] St. Vincent's Instituteof Medical Research,undefined
来源：
Breast Cancer Research and Treatment | 1998年 / 50卷
关键词：
MMP; breast development; breast cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Tissue remodeling is a key process involved in normal development, wound healing, bone remodeling, and embryonic implantation, as well as pathological conditions such as tumor invasion and metastasis, and angiogenesis. The degradation of the extracellular matrix that is associated with those processes is mediated by a number of families of extracellular proteinases. These families include the serine proteinases, such as the plasminogen-urokinase plasminogen activator system and leukocyte elastases, the cysteine proteinases, like cathepsin D and L, and the zinc-dependent matrix metalloproteinases (MMPs) [1]. Accumulating evidence has highlighted the central role of MMP-driven extracellular matrix remodeling in mammary gland development and breast cancer.
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页码：97 / 116
页数：19
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