Structural mechanisms of the agrin–LRP4–MuSK signaling pathway in neuromuscular junction differentiation

被引：0
作者：
Yinong Zong
Rongsheng Jin
机构：
[1] Sanford-Burnham Medical Research Institute,Center for Neuroscience, Aging, and Stem Cell Research
来源：
Cellular and Molecular Life Sciences | 2013年 / 70卷
关键词：
Neuromuscular junction; NMJ development; Acetylcholine receptor; Postsynaptic differentiation; Protein–protein interaction; Signaling pathway; Receptor tyrosine kinase; Wnt signaling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The neuromuscular junction (NMJ) is the most extensively studied model of neuronal synaptogenesis. Acetylcholine receptor (AChR) clustering on the postsynaptic membrane is a cardinal event in the differentiation of NMJs. AChR clustering and postsynaptic differentiation is orchestrated by sophisticated interactions among three proteins: the neuron-secreted proteoglycan agrin, the co-receptor LRP4, and the muscle-specific receptor tyrosine kinase MuSK. LRP4 and MuSK act as scaffolds for multiple binding partners, resulting in a complex and dynamic network of interacting proteins that is required for AChR clustering. In this review, we discuss the structural basis for NMJ postsynaptic differentiation mediated by the agrin–LRP4–MuSK signaling pathway.
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页码：3077 / 3088
页数：11
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