Prediction of protein conformational mobility with validation using small-angle X-ray scattering

被引：1

作者：

Knyazev S.N. ^{[1
]}

Kalyakin V.Y. ^{[1
]}

Deryabin I.N. ^{[1
]}

Fedorov B.A. ^{[1
]}

Smirnov A.V. ^{[1
]}

Stepanov E.O. ^{[1
,2
,3
]}

Porozov Y.B. ^{[1
]}

机构：

[1] ITMO University, Kronverkskiy pr. 49, St. Petersburg

[2] St. Petersburg Department of Steklov Institute of Mathematics of the Russian Academy of Sciences, Fontanki nab. 27, St. Petersburg

[3] St. Petersburg State University, Universitetsky pr. 28, Peterhof, St. Petersburg

来源：

Biophysics | 2015年 / 60卷 / 6期

关键词：

coarse-grained models; conformational paths; motion prediction; protein conformational mobility; small-angle X-ray scattering; transportation problem;

D O I：

10.1134/S0006350915060147

中图分类号：

学科分类号：

摘要：

A “coarse-grained” model of protein conformational mobility is presented. The conformational paths in five proteins, predicted using the model, are compared with those obtained by the nearest-neighbor method basing on the small-angle X-ray scattering data. The sequences of conformations evaluated with the help of these two approaches have been shown for all proteins under consideration to coincide well; yet there are exceptions, their causes having to be considered for each protein separately. © 2015, Pleiades Publishing, Inc.

引用

页码：886 / 892

页数：6

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