A Candidate Gene Study of CYP19 (Aromatase) and Male Sexual Orientation

被引：0
作者：
Michael G. DuPree
Brian S. Mustanski
Sven Bocklandt
Caroline Nievergelt
Dean H. Hamer
机构：
[1] National Cancer Institute,Laboratory of Biochemistry
[2] National Institutes of Health,Department of Anthropology
[3] Pennsylvania State University,Center for Neurobehavioral Genetics
[4] University of California,Department of Psychology
[5] Indiana University,Department of Psychiatry
[6] University of California,undefined
来源：
Behavior Genetics | 2004年 / 34卷
关键词：
Homosexuality; sexual orientation; aromatase; CYP19; linkage; expression;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aromatase cytochrome P450 (CYP19), which is necessary for the conversion of androgens to estrogens, plays an important role in the sexual differentiation of the brain. To investigate whether differences in the gene encoding the aromatase enzyme influence sexual orientation in men, we conducted linkage, association, and expression analyses in a large sample of homosexual brothers using microsatellite markers in and around CYP19. No linkage was detected, and a gene-specific relative risk of 1.5-fold could be excluded at a lod score of −2. Results of the TDT demonstrated no preferential transmission of any of the CYP19 alleles in this sample. Expression of aromatase mRNA by microarray analysis was not significantly different between heterosexual and homosexual men. These results suggest that variation in the gene for this subunit of the aromatase enzyme complex is not likely to be a major factor in the development of individual differences in male sexual orientation.
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页码：243 / 250
页数：7
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