Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer

被引：0
作者：
Christian Geis
Benedikt Grünewald
Andreas Weishaupt
Thomas Wultsch
Klaus V. Toyka
Andreas Reif
Claudia Sommer
机构：
[1] University of Würzburg,Department of Neurology
[2] University of Würzburg,Department of Psychiatry
来源：
Journal of Neural Transmission | 2012年 / 119卷
关键词：
Anti-amphiphysin antibodies; Anxiety; Stiff person syndrome; Amygdala; Passive transfer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.
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页码：981 / 985
页数：4
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共 124 条
[1]  
Ameli R(2005)A neuropsychological assessment of phobias in patients with stiff person syndrome Neurology 64 1961-1963
[2]  
Snow J(2008)Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory Learn Mem 15 163-171
[3]  
Rakocevic G(2009)Stiff person syndrome: advances in pathogenesis and therapeutic interventions Curr Treat Options Neurol 11 102-110
[4]  
Dalakas MC(2001)Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies Neurology 57 780-784
[5]  
Bergado-Acosta JR(2002)Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice Neuron 33 789-804
[6]  
Sangha S(1993)Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer N Engl J Med 328 546-551
[7]  
Narayanan RT(2009)Stiff person syndrome associated anti-amphiphysin antibodies reduce GABA associated [Ca(2 +)]i rise in embryonic motoneurons Neurobiol Dis 36 191-199
[8]  
Obata K(2010)Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition Brain 133 3166-3180
[9]  
Pape HC(2011)Human stiff-person syndrome IgG induces anxious behavior in rats PLoS One 6 e16775-60
[10]  
Stork O(2010)The immunological basis for treatment of stiff person syndrome J Neuroimmunol 231 55-189
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