Prevalance of BRCA1 and BRCA2 mutations in familial breast cancer patients in Lebanon

被引：0
作者：
Nadine Jalkh
Jinane Nassar-Slaba
Eliane Chouery
Nabiha Salem
Nancy Uhrchammer
Lisa Golmard
Domique Stoppa-Lyonnet
Yves-Jean Bignon
André Mégarbané
机构：
[1] Université Saint-Joseph,Unité de Génétique Médicale et laboratoire associé INSERM à l’Unité UMR_S910
[2] Centre Jean Perrin,Département d'Oncogénétique
[3] Université Paris-Descartes,Génétique oncologique, Institut Curie
[4] Université Saint-Joseph,Hôpital, Inserm U830
来源：
Hereditary Cancer in Clinical Practice | / 10卷
关键词：
BRCA1; BRCA2; Breast cancer; Familial; Gene; Lebanon; Mutation;
D O I：
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中图分类号：
学科分类号：
摘要：
Breast cancer is the most prevalent malignancy in women in Western countries, currently accounting for one third of all female cancers. Familial aggregation is thought to account for 5–10 % of all BC cases, and germline mutations in BRCA1 and BRCA2 account for less of the half of these inherited cases. In Lebanon, breast cancer represents the principal death-causing malignancy among women, with 50 % of the cases diagnosed before the age of 50 years.
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