The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP3652 in First-in-Human and Ascending Multiple Oral Dose Studies in Healthy Subjects

[1] Puffenbarger RA(2005)Molecular biology of the enzymes that degrade endocannabinoids Curr Drug Targets CNS Neurol Disord 4 625-631

[2] Lodola A(2015)Fatty acid amide hydrolase inhibitors: a patent review (2009–2014) Expert Opin Ther Pat 25 1247-1266

[3] Castelli R(2005)Retrograde signaling by endocannabinoids Handb Exp Pharmacol 168 367-383

[4] Mor M(2001)Modulation of transmitter release via presynaptic cannabinoid receptors Trends Pharmacol Sci 22 565-572

[5] Rivara S(2010)International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB Pharmacol Rev 62 588-631

[6] Vaughan CW(2011) and CB BJU Int 108 1145-1149

[7] Christie MJ(2002)Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation Prostaglandins Leukot Essent Fatty Acids 66 101-121

[8] Schlicker E(2010)Cannabinoid receptors and their ligands Nat Neurosci 13 1265-1270

[9] Kathmann M(2006)Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism J Neurosci 26 13318-13327

[10] Pertwee RG(2019)Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain Front Mol Neurosci 11 487-483

[1] Puffenbarger RA(2005)Molecular biology of the enzymes that degrade endocannabinoids Curr Drug Targets CNS Neurol Disord 4 625-631

[2] Lodola A(2015)Fatty acid amide hydrolase inhibitors: a patent review (2009–2014) Expert Opin Ther Pat 25 1247-1266

[3] Castelli R(2005)Retrograde signaling by endocannabinoids Handb Exp Pharmacol 168 367-383

[4] Mor M(2001)Modulation of transmitter release via presynaptic cannabinoid receptors Trends Pharmacol Sci 22 565-572

[5] Rivara S(2010)International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB Pharmacol Rev 62 588-631

[6] Vaughan CW(2011) and CB BJU Int 108 1145-1149

[7] Christie MJ(2002)Inhibition of fatty acid amide hydrolase suppresses referred hyperalgesia induced by bladder inflammation Prostaglandins Leukot Essent Fatty Acids 66 101-121

[8] Schlicker E(2010)Cannabinoid receptors and their ligands Nat Neurosci 13 1265-1270

[9] Kathmann M(2006)Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism J Neurosci 26 13318-13327

[10] Pertwee RG(2019)Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain Front Mol Neurosci 11 487-483