Engineering Catharanthus roseus monoterpenoid indole alkaloid pathway in yeast

[1] Besseau S(2013)A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus Plant Physiol 163 1792-1803

[2] Kellner F(2015) production of the plant-derived alkaloid strictosidine in yeast Proc Natl Acad Sci 112 3205-3210

[3] Lanoue A(2018)Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle Science 360 1235-1239

[4] Thamm AM(2018)A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Plant J 94 469-484

[5] Salim V(2021) enables combinatorial synthesis of monoterpene indole alkaloids Molecules 26 3596-421

[6] Schneider B(2008)Optimization of tabersonine methoxylation to increase vindoline precursor synthesis in yeast cell factories J Am Chem Soc 130 420-265

[7] Geu-Flores F(2004)Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(−)-vinblastine Nat Rev Cancer 4 253-2222

[8] Höfer R(1991)Microtubules as a target for anticancer drugs Cancer Res 51 2212-1384

[9] Guirimand G(2007)Mechanism of inhibition by vinca alkaloids Appl Microbiol Biotechnol 75 1377-692

[10] Guihur A(2015)Functional analysis of genes involved in the biosynthesis of isoprene in Plant J 82 680-2699

[1] Besseau S(2013)A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus Plant Physiol 163 1792-1803

[2] Kellner F(2015) production of the plant-derived alkaloid strictosidine in yeast Proc Natl Acad Sci 112 3205-3210

[3] Lanoue A(2018)Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle Science 360 1235-1239

[4] Thamm AM(2018)A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Plant J 94 469-484

[5] Salim V(2021) enables combinatorial synthesis of monoterpene indole alkaloids Molecules 26 3596-421

[6] Schneider B(2008)Optimization of tabersonine methoxylation to increase vindoline precursor synthesis in yeast cell factories J Am Chem Soc 130 420-265

[7] Geu-Flores F(2004)Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(−)-vinblastine Nat Rev Cancer 4 253-2222

[8] Höfer R(1991)Microtubules as a target for anticancer drugs Cancer Res 51 2212-1384

[9] Guirimand G(2007)Mechanism of inhibition by vinca alkaloids Appl Microbiol Biotechnol 75 1377-692

[10] Guihur A(2015)Functional analysis of genes involved in the biosynthesis of isoprene in Plant J 82 680-2699