The role of phenotyping in chronic prostatitis/chronic pelvic pain syndrome

被引：21
作者：
Mahal B.A. [1 ,2 ]
Cohen J.M. [1 ,2 ]
Allsop S.A. [1 ,2 ]
Moore J.B. [1 ,2 ]
Bhai S.F. [1 ,2 ]
Inverso G. [2 ,3 ]
Dimitrakoff J.D. [1 ,2 ]
机构：
[1] Harvard Medical School, Boston, MA 02115
[2] Beth Israel Deaconess Medical Center, Boston, MA 02215
[3] Harvard School of Dental Medicine, Boston, MA 02115
来源：
Current Urology Reports | 2011年 / 12卷 / 4期
关键词：
Chronic prostatitis/chronic pelvic pain syndrome; CP/CPPS; DABBEC; Phenotype; Phenotyping; UPOINT;
D O I：
10.1007/s11934-011-0196-y
中图分类号：
学科分类号：
摘要：
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a chronic pain syndrome identified by the presence of noninfectious pelvic or perineal pain lasting longer than 3 months. Current diagnoses and treatments for the syndrome solely depend on and target symptoms, respectively. Thus far, the mechanistic disturbances responsible for the pathogenesis of CP/CPPS have remained largely elusive and treatments, and therefore, continue to be ineffective. To move toward successful management and treatment of CP/CPPS, it is necessary to elicit the underlying biological mechanisms responsible for the syndrome. Therefore, a phenotyping system that is able to bridge the gap between current symptom-based diagnosis and future mechanistic approaches to diagnosis and treatment is needed. In this article, we examine current CP/CPPS phenotyping systems, analyze their utility, and make suggestions for changes in clinical approaches to the syndrome that would both promulgate a mechanistic understanding and advance treatment approaches. © 2011 Springer Science+Business Media, LLC.
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页码：297 / 303
页数：6
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