Thrombosis in inflammatory bowel diseases: What's the link?

被引：100
作者：
Giannotta M. [1 ]
Tapete G. [1 ]
Emmi G. [2 ]
Silvestri E. [2 ]
Milla M. [1 ]
机构：
[1] AOU Careggi Regional Referral Center for Inflammatory Bowel Disease, Gastroenterology Department, Florence
[2] University of Florence and Patologia Medica Unit, AOU Careggi, Department of Experimental and Clinical Medicine, Florence
来源：
Thrombosis Journal | / 13卷 / 1期
关键词：
Crohn's disease; Inflammatory bowel disease; Thrombosis; Ulcerative colitis;
D O I：
10.1186/s12959-015-0044-2
中图分类号：
学科分类号：
摘要：
Inflammatory bowel disease affects more than 2 million people in Europe, with almost 20% of patients being diagnosed in pediatric age. Patients with inflammatory bowel disease are at increased risk of thromboembolic complications which may affect patients' morbidity and mortality. The risk of the most common thromboembolic events, such as deep venous thrombosis and pulmonary embolism, are estimated to be three-fold increased compared to controls, but many other districts can be affected. Moreover, patients with ulcerative colitis and Crohn's disease experience thromboembolic events at a younger age compared to general population. Many factors have been investigated as determinants of the pro-thrombotic tendency such as acquired risk factors or genetic and immune abnormalities, but a unique cause has not been found. Many efforts have been focused on the study of abnormalities in the coagulation cascade, its natural inhibitors and the fibrinolytic system components and both quantitative and qualitative alterations have been demonstrated. Recently the role of platelets and microvascular endothelium has been reviewed, as the possible link between the inflammatory and hemostatic process. © Giannotta et al.
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共 112 条
[91]  
Collins C.E., Cahill M.R., Newland A.C., Rampton D.S., Platelets circulate in an activated state in inflammatory bowel disease, Gastroenterology, 106, pp. 840-845, (1994)
[92]  
Danese S., Fiocchi C., Platelet activation and the CD40/CD40L pathway: mechanisms and implications for human disease, Crit Rev Immunol, 25, pp. 103-122, (2005)
[93]  
Danese S., Katz J., Saibeni S., Papa A., Gasbarrini A., Vecchi M., Et al., Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients, Gut, 52, pp. 1435-1441, (2003)
[94]  
Danese S., Scaldaferri F., Papa A., Pola R., Gasbarrini A., Sgambato A., Et al., CD40L-positive platelets induce CD40L expression de novo in endothelial cells: adding a loop to microvascular inflammation, Arterioscler Thromb Vasc Biol, 24, (2004)
[95]  
Borcherding F., Nitschke M., Hundorfean G., Rupp J., Smolinski D., Bieber K., Et al., The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease, Am J Pathol, 176, pp. 1816-1827, (2010)
[96]  
Dhillon A.P., Anthony A., Sim R., Wakefield A.J., Sankey E.A., Hudson M., Et al., Mucosal capillary thrombi in rectal biopsies, Histopathology, 21, pp. 127-133, (1992)
[97]  
Collins C.E., Rampton D.S., Rogers J., Williams N.S., Platelet aggregation and neutrophil sequestration in the mesenteric circulation in inflammatory bowel disease, Eur J Gastroenterol Hepatol, 9, pp. 1213-1217, (1997)
[98]  
Cermak J., Key N.S., Bach R.R., Balla J., Jacob H.S., Vercellotti G.M., C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor, Blood, 82, pp. 513-520, (1993)
[99]  
Parry G.C., Mackman N., NF-κB Mediated Transcription in Human Monocytic Cells and Endothelial Cells, Trends Cardiovasc Med, 8, pp. 138-142, (1998)
[100]  
Lindmark E., Tenno T., Siegbahn A., Role of platelet P-selectin and CD40 ligand in the induction of monocytic tissue factor expression, Arterioscler Thromb Vasc Biol, 20, pp. 2322-2328, (2000)
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