Chemical markers for the quality control of herbal medicines: An overview

被引：185
作者：
Li S. [1 ]
Han Q. [1 ]
Qiao C. [1 ]
Song J. [1 ]
Cheng C.L. [1 ]
Xu H. [1 ]
机构：
[1] Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong SAR
来源：
Chinese Medicine | / 3卷 / 1期
关键词：
Herbal Medicine; Rutin; Ginsenoside; Chemical Marker; Gambogic Acid;
D O I：
10.1186/1749-8546-3-7
中图分类号：
学科分类号：
摘要：
Selection of chemical markers is crucial for the quality control of herbal medicines, including authentication of genuine species, harvesting the best quality raw materials, evaluation of post-harvesting handling, assessment of intermediates and finished products, and detection of harmful or toxic ingredients. Ideal chemical markers should be the therapeutic components of herbal medicines. However, for most herbal medicines, the therapeutic components have not been fully elucidated or easily monitored. Bioactive, characteristic, main, synergistic, correlative, toxic and general components may be selected. This article reviews the effective use of chemical markers in the quality control of herbal medicines including the selection criteria considering the roles and physicochemical factors which may affect the effective use of chemical markers. © 2008 Li et al; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 133 条
[91]  
Kaouadji M., Pachtere F., Pouget C., Chulia A.J., Three additional phthalide derivatives, an epoxymonomer and two dimers, from Ligusticum wallichi rhizomes, J Nat Prod, 49, pp. 872-877, (1986)
[92]  
Naito T., Katsuhara T., Niitsu K., Ikeya Y., Okada M., Mitsuhashi H., Phthalide dimers from Ligusticum chuanxiong Hort, Heterocycles, 32, pp. 2433-2442, (1991)
[93]  
Naito T., Kubota K., Shimoda Y., Sato T., Ikeya Y., Okada M., Effects of constituents in a Chinese crude drug, Ligustici Chuanxiong Rhizoma on vasocontracton and blood viscosity, Nat Med, 49, pp. 288-292, (1995)
[94]  
Kobayashi S., Mimura Y., Notoya K., Kimura I., Kimura M., Antiproliferative effects of the traditional Chinese medicine Shimotsu-To, its component Cnidium Rhizome and derived compounds on primary cultures of mouse aorta smooth muscle cells, Jap J Pharmacol, 60, pp. 397-401, (1992)
[95]  
Kobayashi S., Mimura Y., Naito Y., Kimura I., Kimura M., Chemical structure-activity of Cnidium Rhizome - Derived phthalides for the competence inhibition of proliferation in primary cultures of mouse aorta smooth muscle cells, Jap J Pharmacol, 63, pp. 353-359, (1993)
[96]  
Foye W.O., Wang H.P., Wang H.F., Synthesis and platelet aggregation inhibitory effects of Harman and phthalide derivatives related to Ligusticum chuanxiong Hort. Constituents, Med Chem Res, 7, pp. 180-191, (1997)
[97]  
Lee T.F., Lin Y.L., Huang Y.T., Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells, Planta Med, 73, pp. 527-534, (2007)
[98]  
Chan S.S., Cheng T.Y., Lin G., Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta, J Ethnopharmacol, 111, pp. 677-680, (2007)
[99]  
Chan S.S., Choi A.O., Jones R.L., Lin G., Mechanisms underlying the vasorelaxing effects of butylidenephthalide, an active constituent of Ligusticum chuanxiong, in rat isolated aorta, Eur J Pharmacol, 537, pp. 111-117, (2006)
[100]  
Li S.L., Lin G., Tam Y.K., Time-course accumulation of main bioactive components in the rhizome of Ligusticum chuanxiong, Planta Med, 72, pp. 278-280, (2006)
567891011121314