Ureaplasma/Mycoplasma-infected amniotic fluid: Pregnancy outcome in treated and nontreated patients

被引：40
作者：
Berg T.G. [1 ,2 ]
Philpot K.L. [1 ]
Welsh M.S. [1 ]
Sanger W.G. [1 ]
Smith C.V. [1 ]
机构：
[1] Division of Maternal-Fetal Medicine, Munroe Meyer Inst. Genet. and Rehab., Nebraska Medical Center, Omaha, NE
[2] Obstetrics and Gynecology, Nebraska Health System, 983255 Nebraska Medical Center, Omaha
来源：
Journal of Perinatology | 1999年 / 19卷 / 4期
关键词：
D O I：
10.1038/sj.jp.7200185
中图分类号：
学科分类号：
摘要：
OBJECTIVE: To determine if treatment of a positive amniotic fluid culture for mycoplasmal colonization obtained at genetic amniocentesis is associated with improved pregnancy outcome. STUDY DESIGN: A retrospective analysis of 2718 genetic amniocentesis specimens cultured for Ureaplasma/Mycoplasma was undertaken. Specimens were obtained between March 1993 and January 1997. The Irvine culture kit was used to culture all specimens. Data collected included indication for amniocentesis, gestational age at amniocentesis, karyotype, gestational age at delivery, pregnancy outcome, and any antimicrobial treatment. RESULTS: During this time period 44 patients were found to be culture-positive for Ureaplasma/Mycoplasma. Thirty-five were treated with oral erythromycin. Mid-trimester loss was 11.4% and 44.4% (p = 0.04) in the treated and untreated groups, respectively. Preterm delivery was similar in the two groups, 19.4% and 20% (p = NS). CONCLUSION: Treatment of an amniotic mycoplasmal colonization with erythromycin was associated with fewer mid-trimester losses after genetic amniocentesis. Preterm delivery rates between the two groups were similar, which may indicate recolonization.
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页码：275 / 277
页数：2
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