Pulmonary Hypertension in Patients with Chronic Obstructive Pulmonary DiseaseAdvances in Pathophysiology and Management

被引：0
作者：
Joan Albert Barberà
Isabel Blanco
机构：
[1] Universitat de Barcelona,Department of Pulmonary Medicine, Hospital Clinic
[2] CIBER de Enfermedades Respiratorias,Servei de Pneumologia
[3] Hospital Clínic,undefined
来源：
Drugs | 2009年 / 69卷
关键词：
Chronic Obstructive Pulmonary Disease; Pulmonary Hypertension; Pulmonary Arterial Hypertension; Chronic Obstructive Pulmonary Disease Patient; Pulmonary Artery Pressure;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pulmonary hypertension (PH) is an important complication in the natural history of chronic obstructive pulmonary disease (COPD). Its presence is associated with reduced survival and greater use of healthcare resources. The prevalence of PH is high in patients with advanced COPD, whereas in milder forms it might not be present at rest but may develop during exercise. In COPD, PH is usually of moderate severity and progresses slowly, without altering right ventricular function in the majority of patients. Nevertheless, a small subgroup of patients (1–3%) may present with out-of-proportion PH, that is, with pulmonary arterial pressure largely exceeding the severity of airway impairment. These patients depict a clinical picture similar to more severe forms of PH and have higher mortality rates.
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页码：1153 / 1171
页数：18
相关论文
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  • [1] Barberà JA(2003)Pulmonary hypertension in chronic obstructive pulmonary disease Eur Respir J 21 892-905
  • [2] Peinado VI(1994)Pulmonary vascular abnormalities and ventilation-perfusion relationships in mild chronic obstructive pulmonary disease Am J Respir Crit Care Med 149 423-9
  • [3] Santos S(1998)Endothelial dysfunction in pulmonary arteries of patients with mild COPD Am J Physiol 274 L908-13
  • [4] Barberà JA(2002)Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD Eur Respir J 19 632-8
  • [5] Riverola A(2004)Guidelines on diagnosis and treatment of pulmonary arterial hypertension The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur Heart J 25 2243-78
  • [6] Roca J(2008)Pulmonary arterial pressure at rest and during exercise in normal controls Eur Respir J 32 261-55
  • [7] Peinado VI(2007)Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary Am J Respir Crit Care Med 176 532-22
  • [8] Barberà JA(2002)Hemodynamic characterization of patients with severe emphysema Am J Respir Crit Care Med 166 314-94
  • [9] Ramirez J(2005)Severe pulmonary hypertension and chronic obstructive pulmonary disease Am J Respir Crit Care Med 172 189-6
  • [10] Santos S(2005)Pulmonary hemodynamics in advanced COPD candidates for lung volume reduction surgery or lung transplantation Chest 127 1531-24
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