Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma

被引：0

作者：

Hee Seok Yang

Jaehoon Shin

Suk Ho Bhang

Jung-Youn Shin

Jooyeon Park

Gun-Il Im

Chang-Sung Kim

Byung-Soo Kim

机构：

[1] School of Chemical and Biological Engineering,Department of Orthopaedics

[2] Seoul National University,Department of Periodontology

[3] Seoul 151-744,undefined

[4] Korea.,undefined

[5] Dongguk University International Hospital,undefined

[6] Goyang 411-773,undefined

[7] Korea.,undefined

[8] College of Dentistry,undefined

[9] Yonsei University,undefined

[10] Seoul 120-752,undefined

[11] Korea.,undefined

来源：

Experimental & Molecular Medicine | 2011年 / 43卷

关键词：

angiogenesis inducing agents; endothelial growth factors; fibrin; fibroblast growth factor 2; heparin; neovascularization, physiologic; platelet-derived growth factor; platelet-rich plasma; wound healing;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Platelet-rich plasma (PRP) contains growth factors that promote tissue regeneration. Previously, we showed that heparin-conjugated fibrin (HCF) exerts the sustained release of growth factors with affinity for heparin. Here, we hypothesize that treatment of skin wound with a mixture of PRP and HCF exerts sustained release of several growth factors contained in PRP and promotes skin wound healing. The release of fibroblast growth factor 2, platelet-derived growth factor-BB, and vascular endothelial growth factor contained in PRP from HCF was sustained for a longer period than those from PRP, calcium-activated PRP (C-PRP), or a mixture of fibrin and PRP (F-PRP). Treatment of full-thickness skin wounds in mice with HCF-PRP resulted in much faster wound closure as well as dermal and epidermal regeneration at day 12 compared to treatment with either C-PRP or F-PRP. Enhanced skin regeneration observed in HCF-PRP group may have been at least partially due to enhanced angiogenesis in the wound beds. Therefore, this method could be useful for skin wound treatment.

引用

页码：622 / 629

页数：7

共 165 条

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