Impact of 18F-FDG-PET/CT on Staging and Irradiation of Patients with Locally Advanced Rectal Cancer

被引：28
作者：
Paskeviciute, Brigita [1 ]
Boelling, Tobias [1 ]
Brinkmann, Markus [1 ]
Rudykina, Ganna [1 ]
Ernst, Iris [1 ]
Stegger, Lars [2 ]
Schober, Otmar [2 ]
Willich, Normann [1 ]
Weckesser, Matthias [2 ]
Koenemann, Stefan [1 ]
机构：
[1] Univ Hosp Munster, Dept Radiotherapy, D-48129 Munster, Germany
[2] Univ Hosp Munster, Dept Nucl Med, D-48129 Munster, Germany
来源：
STRAHLENTHERAPIE UND ONKOLOGIE | 2009年 / 185卷 / 04期
关键词：
FDG; PET/CT; Rectal cancer; Radiotherapy; POSITRON-EMISSION-TOMOGRAPHY; COLORECTAL LIVER METASTASES; INTENSITY-MODULATED RADIOTHERAPY; TARGET VOLUME DELINEATION; TOTAL MESORECTAL EXCISION; RADIATION-THERAPY; PET-CT; MANAGING PATIENTS; FDG-PET; MANAGEMENT;
D O I：
10.1007/s00066-009-1962-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To investigate the impact of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) on planning of neoadjuvant radiotherapy for locally advanced rectal cancer (LARC) patients. From January 2003 to December 2007, a total of 36 patients with LARC underwent a retroprospective PET/CT study for radiotherapy-planning purposes. Gross tumor volume (GTV), clinical target volume (CTV) and planning target volume (PTV) were defined in a retrospective analysis by a blinded reader. The hypothetical boost volume was defined primarily on CT alone, and afterwards on the fused PET/CT dataset. The CT- and PET/CT-based GTVs were quantitatively compared and percentage of overlap (OV%) was calculated and analyzed. The impact of PET/CT on radiation treatment planning and overall patient management was evaluated. PET/CT-GTVs were smaller than CT-GTVs (p < 0.05). PET/CT imaging resulted in a change of overall management for three patients (8 %). In 16 of 35 patients (46 %), PET/CT resulted in a need for modification of the usual target volumes (CT-PTV) because of detection of a geographic miss. FDG-PET/CT had significant impact on radiotherapy planning and overall treatment of patients with LARC.
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收藏
页码：260 / 265
页数：6
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