Drug-induced anaphylaxis—elicitors, mechanisms and diagnosis

被引：0

作者：

Margitta Worm

Theresa Hanschmann-Mohn

Kathrin Scherer Hofmeier

Victòria Cardona

Paul Turner

Sabine Dölle-Bierke

机构：

[1] Dpt. of Allergy and Dermatology,Division of Allergy and Immunology

[2] Charité – Universitätsmedizin Berlin,Division of Allergy

[3] Dpt. of Dermatology,S. Allergologia, S. Medicina Interna

[4] University Hospital Basel,Imperial College Healthcare NHS Trust

[5] University of Basel,undefined

[6] Hospital Vall d’Hebron,undefined

[7] St Mary’s Hospital,undefined

来源：

Allergo Journal International | 2019年 / 28卷

关键词：

Allergy; Intolerance; β‑lactams; Analgetics; Provocation tests;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Drugs are one of the major causes of anaphylaxis. For example 2346 cases of drug-induced anaphylaxis were reported to the anaphylaxis register as of March 2019. The most common triggers of drug-induced anaphylaxis were nonsteroidal anti-inflammatory drugs (NSAIDs; n = 902) and antibiotics (n = 721). Drug-induced anaphylaxis can be caused by IgE-dependent (e.g., penicillins) and IgE-independent mechanisms. Recently MRG-PX2 has been identified as a receptor for non-IgE-dependent mechanisms. Drug-induced anaphylaxis results more frequently in lethal reactions and is more commonly associated with cardiovascular symptoms. Also therapy refractory anaphylaxis is more frequently triggered by drugs. For the diagnosis of drug-induced anaphylaxis current national and international guidelines should be followed including provocation tests to avoid future reactions.

引用

页码：327 / 329

页数：2

共 42 条

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