A/H5N1 Prepandemic Influenza Vaccine (Vepacel®): A Guide to Its Use

被引：0
作者：
Gillian M. Keating
Greg L. Plosker
Katherine A. Lyseng-Williamson
机构：
[1] Adis,
来源：
BioDrugs | 2012年 / 26卷 / 6期
关键词：
Influenza; Avian Influenza; Influenza Vaccine; H5N1 Virus; Booster Vaccination;
D O I：
10.1007/BF03261899
中图分类号：
学科分类号：
摘要：
Vepacel® is a prepandemic influenza vaccine (whole virion, Vero cell-derived, inactivated) containing antigen of H5N1 strain A/Vietnam/1203/2004 and is approved for use in the EU. Clinical immunogenicity studies with the vaccine have demonstrated good functional neutralizing antibody responses against the vaccine strain (A/Vietnam/1203/2004), and cross-reactivity against H5N1 strains from other clades. In general, adverse events observed in clinical immunogenicity studies with a whole virions H5N1 vaccine (A/Vietnam/1203/2004) were similar to those reported with non-adjuvanted, inactivated, split virion seasonal influenza vaccines.
引用
收藏
页码：425 / 430
页数：5
相关论文
共 26 条
[1]  
Jennings L.C.(2008)Stockpiling prepandemic influenza vaccines: a new cornerstone of pandemic preparedness plans Lancet Infect Dis 8 650-8
[2]  
Monto A.S.(2008)Vaccine preparedness: are we ready for the next influenza pandemic? N Engl J Med 358 2540-3
[3]  
Chan P.K.(2006)Strategies for mitigating an influenza pandemic Nature 442 448-52
[4]  
Wright P.F.(2012)A/H5N1 Prepandemic influenza vaccine (whole virion, Vero cell-derived, inactivated) [Vepacel®] Drugs 72 1543-57
[5]  
Ferguson N.M.(1998)Development of a mammalian cell (Vero) derived candidate influenza virus vaccine Vaccine 16 960-8
[6]  
Cummings D.A.(2009)Vero cell platform in vaccine production: moving towards cell culture-based viral vaccines Expert Rev Vaccines 8 607-18
[7]  
Fraser C.(2008)A clinical trial of a whole-virus H5N1 vaccine derived from cell culture N Engl J Med 358 2573-84
[8]  
Plosker G.L.(2009)A cell culture (Vero)-derived H5N1 whole-virus vaccine induces cross-reactive memory responses J Infect Dis 200 1113-8
[9]  
Kistner O.(2010)Evaluation of the cellular immune responses induced by a non-adjuvanted inactivated whole virus A/H5N1/VN/1203 pandemic influenza vaccine in humans Vaccine 29 166-73
[10]  
Barrett P.N.(2012)Cell culture (Vero cell) derived whole-virus non-adjuvanted H5N1 influenza vaccine induces long-lasting cross-reactive memory immune response: homologous or heterologous booster response following two dose or single dose priming Vaccine 30 6127-35
123