Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors

[1] Crosio C(2002)Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases Mol Cell Biol 22 874-885

[2] Fimia GM(1999)The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis Trends Cell Biol 9 454-459

[3] Loury R(2003)The cellular geography of aurora kinases Nat Rev Mol Cell Biol 4 842-854

[4] Kimura M(1999)Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases J Cell Sci 112 3591-3601

[5] Okano Y(2001)Mitotic kinases as regulators of cell division and its checkpoints Nat Rev Mol Cell Biol 2 21-32

[6] Zhou H(1998)Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation Nat Genet 20 189-193

[7] Sen S(2002)Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis Cancer Res 62 4115-4122

[8] Allis CD(2006)Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation Oncogene 25 7148-7158

[9] Sassone-Corsi P(2004)Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models Oncogene 23 8720-8730

[10] Bischoff JR(2008)Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer Clin Cancer Res 14 4455-4462

[1] Crosio C(2002)Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases Mol Cell Biol 22 874-885

[2] Fimia GM(1999)The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis Trends Cell Biol 9 454-459

[3] Loury R(2003)The cellular geography of aurora kinases Nat Rev Mol Cell Biol 4 842-854

[4] Kimura M(1999)Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases J Cell Sci 112 3591-3601

[5] Okano Y(2001)Mitotic kinases as regulators of cell division and its checkpoints Nat Rev Mol Cell Biol 2 21-32

[6] Zhou H(1998)Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation Nat Genet 20 189-193

[7] Sen S(2002)Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis Cancer Res 62 4115-4122

[8] Allis CD(2006)Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation Oncogene 25 7148-7158

[9] Sassone-Corsi P(2004)Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models Oncogene 23 8720-8730

[10] Bischoff JR(2008)Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer Clin Cancer Res 14 4455-4462