One-pot synthesis of trisubstituted pyrazoles via multicomponent approach

被引：0
作者：
P. Santhosh
V. S. R. Chunduru
V. Rajeswar Rao
机构：
[1] National Institute of Technology,Department of Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2011年 / 47卷
关键词：
acetylacetone; 3-(2-bromoacetyl)coumarins; hydrazine hydrate; phenacyl bromides; pyrazole; one-pot; multicomponent reactions;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An efficient one-pot multicomponent reaction for the synthesis of 1-aryl- or 1-heteryl-substituted 3,5-dimethylpyrazoles with excellent yields has been described. Reaction of 3-(2-bromoacetyl)coumarins or phenacyl bromides with acetylacetone and hydrazine hydrate in ethanol afforded the corresponding 3,5-dimethylpyrazoles in good yields. All the synthesized compounds were characterized by their analytical and spectral data.
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页码：448 / 451
页数：3
相关论文
共 55 条
[1]  
Jähnisch K(2004)undefined Angew. Chem. Int. Ed 43 406-undefined
[2]  
Hessel V(1997)undefined Chem. Heterocycl. Comp. 33 647-undefined
[3]  
Löwe H(2007)undefined Eur. J. Med. Chem. 42 403-undefined
[4]  
Baerns M(1993)undefined J. Med. Chem. 36 134-undefined
[5]  
Lévai A(2007)undefined Eur. J. Med. Chem. 42 30-undefined
[6]  
Özdemir A(2005)undefined Bioorg. Med. Chem. Lett. 15 4632-undefined
[7]  
Turan-Zitouni G(2004)undefined Bioorg. Med. Chem. Lett. 14 4461-undefined
[8]  
Kaplancıklı ZA(2001)undefined Eur. J. Med. Chem. 36 81-undefined
[9]  
Revial G(2000)undefined Bioorg. Med. Chem. 8 2701-undefined
[10]  
Güven K(2006)undefined Synth. Commun. 36 2157-undefined
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