Immunotherapy with heat shock protein 96 to treat gliomas

被引：6

作者：

Li C. ^{[1
]}

Du Y. ^{[2
]}

Zhang Y. ^{[1
,3
,4
]}

Ji N. ^{[1
]}

机构：

[1] Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing

[2] Beijing Shijitan Hospital, Capital Medical University, No.10 Yangfangdian Road, Fengtai District, Beijing

[3] China National Clinical Research Center Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing

[4] Beijing Key Laboratory of Brian Tumor, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing

来源：

Chinese Neurosurgical Journal | / 6卷 / 1期

关键词：

Glioma; gp96; Oncogenesis; Tumor vaccine;

D O I：

10.1186/s41016-020-00211-3

中图分类号：

学科分类号：

摘要：

Heat shock protein 96 (gp96) is a highly conserved protein in the endoplasmic reticulum. The functions of gp96 include promoting the oncogenesis and progression of glioma. In addition, tumor-derived gp96 can activate anti-tumor immune. Therefore, this protein was used to generate an anti-tumor vaccine and widely applied to glioma therapy. This review summarizes the mechanisms of gp96 in glioma oncogenesis and clinical trials of the gp96 tumor vaccine in glioma treatment. © 2020 The Author(s).

引用

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