Targeting ErbB3-mediated stromal–epithelial interactions in pancreatic ductal adenocarcinoma

被引:0
作者
J S Liles
J P Arnoletti
A V Kossenkov
A Mikhaylina
A R Frost
P Kulesza
M J Heslin
A Frolov
机构
[1] University of Alabama at Birmingham,Department of Surgery
[2] The Wistar Institute,Systems Biology Division
[3] University of Alabama at Birmingham,Department of Pathology
[4] Northwestern University,Department of Pathology
来源
British Journal of Cancer | 2011年 / 105卷
关键词
ErbB3; EGFR; pancreatic cancer; ErbB3 antibody; tumourigenesis;
D O I
暂无
中图分类号
学科分类号
摘要
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收藏
页码:523 / 533
页数:10
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[11]  
Posey J(2007)ErbB3 expression and dimerization with EGFR influence pancreatic cancer cell sensitivity to erlotinib Cancer Biol Ther 6 548-554
[12]  
Wood T(2003)The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation Proc Natl Acad Sci USA 100 8933-8938
[13]  
Greeno E(2008)Cancer-associated stromal fibroblasts promote pancreatic tumor progression Cancer Res 68 918-926
[14]  
Jhala N(2009)Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials Clin Cancer Res 15 5267-5273
[15]  
Varadarajulu S(2009)Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab J Clin Oncol 27 5068-5074
[16]  
Russo S(2006)C-fos assessment as a marker of anti-epidermal growth factor receptor effect Cancer Res 66 2385-2390
[17]  
Christein J(2009)Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3 Proc Natl Acad Sci USA 106 21608-21613
[18]  
Oster R(2007)Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab J Clin Oncol 25 3230-3237
[19]  
Buchsbaum DJ(1994)Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product J Biol Chem 269 24747-24755
[20]  
Vickers SM(2007)Expression and differential signaling of heregulins in pancreatic cancer cells Int J Cancer 120 514-523