A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans

被引：6

作者：

Moksnes, Marta R. ^{[1
]}

Hansen, Ailin F. ^{[1
]}

Wolford, Brooke N. ^{[1
]}

Thomas, Laurent F. ^{[1
,2
,3
,4
]}

Rasheed, Humaira ^{[1
,5
,6
]}

Simic, Anica ^{[7
]}

Bhatta, Laxmi ^{[1
]}

Brantsaeter, Anne Lise ^{[8
]}

Surakka, Ida ^{[9
]}

Zhou, Wei ^{[10
,11
,12
]}

Magnus, Per ^{[13
]}

Njolstad, Pal R. ^{[14
,15
]}

Andreassen, Ole A. ^{[16
,17
]}

Syversen, Tore ^{[18
]}

Zheng, Jie ^{[19
,20
,21
]}

Fritsche, Lars G. ^{[22
,23
]}

Evans, David M. ^{[24
,25
,26
]}

Warrington, Nicole M. ^{[1
,24
,25
,26
]}

Nost, Therese H. ^{[1
,27
]}

Asvold, Bjorn Olav ^{[1
,28
,29
]}

Flaten, Trond Peder ^{[7
]}

Willer, Cristen J. ^{[1
,10
,30
,31
]}

Hveem, Kristian ^{[1
,28
]}

Brumpton, Ben M. ^{[1
,28
,32
]}

机构：

[1] NTNU Norwegian Univ Sci & Technol, HUNT Ctr Mol & Clin Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway

[2] NTNU Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway

[3] NTNU Norwegian Univ Sci & Technol, BioCore Bioinformat Core Facil, Trondheim, Norway

[4] Trondheim Reg & Univ Hosp, St Olavs Hosp, Clin Lab Med, Trondheim, Norway

[5] Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, England

[6] Univ Oslo, Div Med & Lab Sci, Oslo, Norway

[7] NTNU Norwegian Univ Sci & Technol, Dept Chem, Trondheim, Norway

[8] Norwegian Inst Publ Hlth, Dept Food Safety, Div Climate & Environm Hlth, Oslo, Norway

[9] Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI USA

[10] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI USA

[11] Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA USA

[12] Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA

[13] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway

[14] Univ Bergen, Mohn Ctr Diabet Precis Med, Dept Clin Sci, Bergen, Norway

[15] Haukeland Hosp, Children & Youth Clin, Bergen, Norway

[16] Univ Oslo, NORMENT Ctr, Oslo, Norway

[17] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway

[18] NTNU Norwegian Univ Sci & Technol, Dept Neurosci, Trondheim, Norway

[19] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China

[20] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Digital Med Innovat Ctr, Sch Med,Shanghai Natl Clin Res Ctr Metab Dis,Key L, Shanghai, Peoples R China

[21] Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Bristol, England

[22] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI USA

[23] Univ Michigan, Ctr Stat Genet, Sch Publ Hlth, Ann Arbor, MI USA

[24] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

[25] Univ Queensland, Frazer Inst, Woolloongabba, Qld, Australia

[26] Univ Bristol, MRC Integrat Epidemiol Unit IEU, Bristol, England

[27] UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway

[28] NTNU Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Nursing, Levanger, Norway

[29] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Endocrinol, Clin Med, Trondheim, Norway

[30] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI USA

[31] Univ Michigan, Dept Human Genet, Ann Arbor, MI USA

[32] Trondheim Reg & Univ Hosp, St Olavs Hosp, Clin Med, Trondheim, Norway

来源：

COMMUNICATIONS BIOLOGY | 2024年 / 7卷 / 01期

基金：

欧盟地平线“2020”; 美国国家卫生研究院;

关键词：

PARKINSONS-DISEASE; NORWEGIAN MOTHER; IRON-METABOLISM; COHORT PROFILE; CHILD COHORT; VITAMIN-D; BLOOD; ZINC; MANGANESE; SELENIUM;

D O I：

10.1038/s42003-024-06101-z

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. Here we report a comprehensive multi-element genome-wide association study of 57 essential and non-essential trace elements. We perform genome-wide association meta-analyses of 14 trace elements in up to 6564 Scandinavian whole blood samples, and genome-wide association studies of 43 trace elements in up to 2819 samples measured only in the Tr & oslash;ndelag Health Study (HUNT). We identify 11 novel genetic loci associated with blood concentrations of arsenic, cadmium, manganese, selenium, and zinc in genome-wide association meta-analyses. In HUNT, several genome-wide significant loci are also indicated for other trace elements. Using two-sample Mendelian randomization, we find several indications of weak to moderate effects on health outcomes, the most precise being a weak harmful effect of increased zinc on prostate cancer. However, independent validation is needed. Our current understanding of trace element-associated genetic variants may help establish consequences of trace elements on human health. A genome-wide association study of 57 trace elements measured in up to 6564 Scandinavians, identifies genetic loci associated with blood levels of essential and non-essential trace elements and explores their effects on health outcomes.

引用

页数：14

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