Differential mechanisms of urethral smooth muscle relaxation by several NO donors and nitric oxide

被引：0

作者：

A. García-Pascual

G. Costa

A. Labadía

E. Jimenez

D. Triguero

机构：

[1] Departamento de Fisiología,

[2] Facultad de Veterinaria,undefined

[3] Universidad Complutense,undefined

[4] E-28040 Madrid,undefined

[5] Spain e-mail: vefis12@sis.ucm.es,undefined

[6] Fax: +34-91-3943864,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 1999年 / 360卷

关键词：

Key words Urethra; Nitric oxide; NO donors; S-nitrosothiols; Sodium nitroprusside; Glyceryl trinitrate; cGMP; Thiol modulators;

D O I：

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学科分类号：

摘要：

We have examined the mechanisms of action of a broad spectrum of nitric oxide (NO) donors, including several S-nitrosothiols, sodium nitroprusside (SNP) and nitroglycerine (GTN), in relation to their relaxant activity of urethral smooth muscle. For all the compounds examined, NO release (in solution and in the presence of urethral tissue), relaxation responses, elevations in cGMP levels and the effect of thiol modulators were evaluated and compared with the effect of NO itself.

引用

页码：80 / 91

页数：11