It is very important to predict the blasting fragmentation size of fractured rock mass. Based on the geological conditions of practical engineering rock mass, a plane analysis model of bench blasting in layered rock mass considering microcrack structure was established. And the distribution law of stress in the bench blasting of layered rock mass with different occurrence and layer thickness is analyzed by using the CDEM numerical simulation method. Combined with the theory of rock fracture mechanics and relevant test results, this paper quantitatively studied the change laws of the angle for the cracks to propagate, speed and crack initiation length at different particle points in bench blasting and realized the time history analysis of the crack development and rock fragmentation in bench blasting. And then, this paper derived the quantitative relationship between the post-expansion cranny ratio and the blasting fragmentation from a theoretical point of view, and proposed the prediction method of the median fragmentation in bench blasting of layered rock mass. Combined with the bench blasting productive test of Changjiu (Shenshan) limestone mine, the largest sand aggregate production mine in the world, the correctness of the theoretical results is verified. The test results demonstrate that in a vertically inclined rock bench, the degree of rock fragmentation intensifies in the horizontal direction, and the overall fragmentation effect can be optimized by adjusting the blasting hole spacing; the blasting fragmentation prediction method proposed in the paper can accurately predict the median fragmentation of layered rock, which provides a novel method for predicting the effects of bench blasting.