Localized Relapse in Bone Marrow in a Posttransplantation Patient with t(6;9) Acute Myeloid Leukemia

被引：0
作者：
Tetsuo Maeda
Satoru Kosugi
Hidetoshi Ujiie
Kazuoki Osumi
Takashi Fukui
Hitoshi Yoshida
Hirokazu Kashiwagi
Jun Ishikawa
Yoshiaki Tomiyama
Yuji Matsuzawa
机构：
[1] Osaka University,Department of Internal Medicine and Molecular Science, Graduate School of Medicine
[2] Otsuka Pharmaceuticals Co Ltd,Otsuka Assay Laboratory
来源：
International Journal of Hematology | 2003年 / 77卷
关键词：
Real-time PCR; DEK-CAN; Minimal residual disease; MRD; Acute myeloid leukemia; AML; Bone marrow transplantation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We report a 38-year-old woman with t(6;9) acute myeloid leukemia who relapsed with localized leukemic cell growth in the bone marrow after she had undergone allogeneic bone marrow transplantation. The localized cell growth was first recognized by an apparent discrepancy in the DEK-CAN fusion transcript levels between the aspirates from the left and right iliac bone marrow. Magnetic resonance imaging of the iliac bone revealed localized cell accumulation in the left side. The nonhomogeneous and localized leukemic cell growth in this case may have been due to the graft-versus-leukemia effect following allogeneic transplantation with donor lymphocyte infusion. Serial monitoring of molecular markers for leukemia at different sites or magnetic resonance imaging of the bone marrow may be of value in detecting this type of relapse.
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页码：522 / 525
页数：3
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  • [1] Marcucci G(1998)Detection of minimal residual disease in patients with AML1/ ETO-associated acute myeloid leukemia using a novel quantitative reverse transcription polymerase chain reaction assay Leukemia 12 1482-1489
  • [2] Livak K(1992)The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA Mol Cell Biol 12 1687-1697
  • [3] Bi W(2000)Combination chemotherapy with risk factor-adjusted dose attenuation for high-risk myelodysplastic syndrome and resulting leukemia in the multicenter study of the Japan Adult Leukemia Study Group (JALSG): results of an interim analysis Int J Hematol 72 200-205
  • [4] Strout MP(1987)Nonhomogeneous distribution of leukemia in the bone marrow during minimal residual disease Blood 70 1073-1078
  • [5] Bloomfield CD(1995)Magnetic resonance imaging of femoral marrow in patients with myelodysplastic syndromes or leukemia Blood 86 316-322
  • [6] Caligiuri MA.(2002)Magnetic resonance imaging of femoral marrow predicts outcome in adult patients with acute myeloid leukaemia in complete remission Br J Haematol 117 70-75
  • [7] von Lindern M(2002)Donor lymphocyte infusion: the use of alloreactive and tumor-reactive lymphocytes for immunotherapy of malignant and nonmalignant diseases in conjunction with allogeneic stem cell transplantation J Hematother Stem Cell Res 11 265-276
  • [8] Fornerod M(1992)The translocation (6;9)(p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features Blood 79 2990-2997
  • [9] van Saal S(1993)Translocation t(6;9)(p23;q34) in acute myeloid leukemia without myelodys-plasia or basophilia: two cases and a review of the literature Leukemia 7 527-531
  • [10] Okamoto T(1995)Detection of minimal residual disease in a patient with acute myeloid leukemia and t(6;9) at the time of peripheral blood stem cell transplantation Acta Haematol 94 139-141
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