Interaction of silver nanoparticles with HIV-1

被引：44

作者：

Elechiguerra J.L. ^{[1
]}

Burt J.L. ^{[1
]}

Morones J.R. ^{[1
]}

Camacho-Bragado A. ^{[2
]}

Gao X. ^{[2
]}

Lara H.H. ^{[3
]}

Yacaman M.J. ^{[1
,2
]}

机构：

[1] Department of Chemical Engineering, The University of Texas at Austin, Austin

[2] Texas Materials Institute, The University of Texas at Austin, Austin

[3] Facultad de Ciencias Biológica, Universidad Autónoma de Nuevo León, San Nicolas de los Garza, Nuevo Leon

来源：

Journal of Nanobiotechnology | / 3卷 / 1期

关键词：

Silver Nanoparticles; Surface Enhance Raman Scattering; Nanoparticle Preparation; High Angle Annular Dark Field; High Angle Annular Dark Field Image;

D O I：

10.1186/1477-3155-3-6

中图分类号：

学科分类号：

摘要：

The interaction of nanoparticles with biomolecules and microorganisms is an expanding field of research. Within this field, an area that has been largely unexplored is the interaction of metal nanoparticles with viruses. In this work, we demonstrate that silver nanoparticles undergo a sizedependent interaction with HIV-1, with nanoparticles exclusively in the range of 1-10 nm attached to the virus. The regular spatial arrangement of the attached nanoparticles, the center-to-center distance between nanoparticles, and the fact that the exposed sulfur-bearing residues of the glycoprotein knobs would be attractive sites for nanoparticle interaction suggest that silver nanoparticles interact with the HIV-1 virus via preferential binding to the gp 120 glycoprotein knobs. Due to this interaction, silver nanoparticles inhibit the virus from binding to host cells, as demonstrated in vitro. © 2005 Elechiguerra et al; licensee BioMed Central Ltd.

引用

页数：10

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