Three-dimensional organization of telomeres in nuclei of Drosophila melanogaster Salivary glands

被引：0
作者：
Zakharenko L.P. [1 ,2 ]
Perepelkina M.P. [1 ]
Mai S. [3 ]
机构：
[1] Institute of Cytology and Genetics, Siberian Department, Russian Academy of Sciences, Novosibirsk
[2] Department of Cytology and Genetics, Novosibirsk State University, Novosibirsk
[3] Manitoba Institute of Cell Biology, Cancer Care Manitoba, University of Manitoba, Winnipeg, MB
来源：
Cell and Tissue Biology | 2008年 / 2卷 / 4期
基金：
俄罗斯基础研究基金会; 加拿大健康研究院;
关键词：
Salivary Gland; Telomere Length; Tissue Biology; Polytene Chromosome; Squashed Preparation;
D O I：
10.1134/S1990519X08040068
中图分类号：
学科分类号：
摘要：
3D-FISH method was employed to investigate the telomere topology in polytene nuclei of salivary glands in Drosophila melanogaster. The majority of telomeres in polytene nuclei of salivary glands in Drosophila strain y2-717 is localized in the nuclear central area and have no contacts with nuclear membrane. In the females ectopic contacts between telomeres occur in frequency 25% higher than in males. HeT-A DNA in y2-717alk3-2 strain, which is a derivative of the y2-717 stain carrying an inversion between 1B and 13C bands, is found in the region 13 of X chromosome. The frequency of ectopic contacts of telomeres in y2-717alk3-2 males is 10% higher than in the y2-717 strain. The number of ectopic contacts can be differ significantly in independent experiments, possibly indicating the role of random factors in the contact formation. © MAIK Nauka 2008.
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页码：376 / 380
页数：4
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