Effects of Neostigmine and Physostigmine on Activity of Na+,K+-ATPase in Various Subdivisions of Rat Brain

被引：0
作者：
V. N. Dubrovskii
A. D. Shalabodov
A. V. Belkin
机构：
[1] Tyumen State University,
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 166卷
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摘要：
The effects of intramuscular administration of neostigmine and physostigmine on Na+,K+-ATPase activity in various cerebral subdivisions were examined in rats. In CNS and peripheral tissues, both agents rapidly and significantly reduced activity of cholinesterases by 30-50%. The development of intoxication did not change the marker indices of stress reaction. In the cerebral cortex, physostigmine increased Na+,K+-ATPase activity, whereas neostigmine suppressed it. In addition, neostigmine decreased activity of this enzyme in the cerebellum. In contrast, both agents produced no effects on Na+,K+-ATPase activity in the striatum. The data corroborate the view on functional interaction between Na+,K+-ATPase and nicotinic cholinoreceptors in rat cerebral cortex.
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页码：50 / 53
页数：3
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