The adrenal and the metabolic syndrome

被引：11

作者：

Golub M.S. ^{[1
]}

机构：

[1] Veterans Affairs Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center, Sepulveda, CA 91343

来源：

Current Hypertension Reports | 2001年 / 3卷 / 2期

关键词：

Cortisol; Metabolic Syndrome; DHEA; Central Obesity; Insulin Resistance Syndrome;

D O I：

10.1007/s11906-001-0022-x

中图分类号：

学科分类号：

摘要：

This review discusses the possible interrelationships between adrenal steroid hormones and the metabolic syndrome. Abnormal regulation of the hypothalamicpituitary- adrenal axis has been proposed. Studies in the United Kingdom associated the metabolic syndrome with low birth weight and hyperactivity of the entire axis. In Italy, increased pituitary responsiveness to stimulation with vasopressin and corticotrophin-releasing hormone was demonstrated in women with central obesity. Swedish researchers have reported that increased stress responses of the axis correlated with a less variable but decreased cortisol level. An allele of the glucocorticoid receptor was also associated with various components of the metabolic syndrome. Evidence also suggests that central obesity is associated with an increased peripheral conversion of cortisol to cortisone and subsequent feedback stimulation of the axis. On the other hand, central fat may have an increased local metabolism in the direction of cortisol. Roles for dehydroepiandrosterone and aldosterone in the syndrome have also been proposed. Copyright © 2001 by Current Science Inc.

引用

页码：117 / 120

页数：3

共 22 条

[1]

Aron D.C., Endocrine incidentalomas, Endocrinol Metab Clin North Am, 29, pp. 1-229, (2000)

[2]

Landsberg L., Role of the sympathetic adrenal system in the pathogenesis of the insulin resistance syndrome, Ann N y Acad Sci, 892, pp. 84-90, (1999)

[3]

Andrews R.C., Walker B.R., Glucocorticoids and insulin resistance: Old hormones, new targets, Clin Sci, 96, pp. 513-523, (1999)

[4]

Phillips D.I., Barker D.J., Fall C.H., Et al., Elevated plasma cortisol concentrations: A link between low birth weight and the insulin resistance syndrome?, J Clin Endocrinol Metab, 83, pp. 757-760, (1998)

[5]

Phillips D.I., Walker B.R., Reynolds R.M., Et al., Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations, Hypertension, 35, pp. 1301-1306, (2000)

[6]

Benediktsson R., Lindsay R.S., Nobel J., Et al., Glucocorticoid exposure in utero: New model for adult hypertension, Lancet, 341, pp. 339-341, (1993)

[7]

Walker B.R., Phillips D.I., Noon J.P., Et al., Increased glucocorticoid activity in men with cardiovascular risk factors, Hypertension, 31, pp. 891-895, (1998)

[8]

Pasquali R., Cantobelli S., Casimirri F., Et al., The hypothalamicpituitary- adrenal axis in obese women with different patterns of body fat distribution, J Clin Endocrinol Metab, 77, pp. 341-346, (1993)

[9]

Vicennati V., Pasquali R., Abnormalities of the hypothalamicpituitary- adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: Evidence for a central and a peripheral alteration, J Clin Endocrinol Metab, 85, pp. 4093-4098, (2000)

[10]

Pasquali R., Vicennati V., Calzoni F., Et al., Alpha2-adrenoceptor regulation of the hypothalamic-pituitary- adrenocrotical axis in obesity, Clin Endocrinol, 52, pp. 413-421, (2000)

← 1 2 3 →